Elevated high sensitivity C-reactive protein and uric acid levels in coronary artery ectasia

• Authors: Şerafettin Demir , Gulhan Karakoyun , Mehmet Kanadasi
• Languages of publication: EN

Abstracts

EN

Aim: The aim of this study is to examine uric asid (UA) and high sensitive C-Reactive protein (Hs-CRP) levels in patients with coronary artery ectasia (CAE). Materials and Methods: Ninety-eight patients with isolated CAE (mean age 57.5±10.3), (group-I), 110 patients with CAD but without CAE (mean age 56.3±10.7), (group-II), and 105 patients with normal coronary angiographies (mean age 58.1±10.8), (group-III) were included in the study. Blood samples of all individual were taken after coronary angiography from an antecubital vein, the patients uric acid and Hs-CRP levels were assessed. The severity of ectasia was evaluated and categorized according to Markis. Results: A significant difference was not seen in serum uric acid and Hs-CRP levels between CAE and CAD groups. However, relative to the control group, uric acid and Hs-CRP levels in CAE and CAD groups were higher to a significant degree (p=0.001, p<0.001, respectively), (p<0.001, p<0.001, respectively). The statistical significant was detected between subgroups type I and type IV, Hs-CRP and UA were statistically high in subgroup type I. (p=0.012, p=0.033, respectively) In multiple regression analysis, CAE and CAD were independently associated with UA (β=0.76; p<0.001, β=0.68; p<0.001, respectively) and Hs-CRP (β=0.66; p<0.01, β=0.62; p<0.01, respectively) along with diabetes mellitus (β=0.61; p=0.039, β=0.94; p=0.028, respectively). Conclusion: In conclusion, the blood uric acid and Hs-CRP values in our study have been observed to be higher in the individuals with coronary arteri ectasia in comparison to normal individuals, and the increase in these values were found to be parallel to the extent of the ectasia.

Keywords

EN

coronary ectasia; coronary artery disease; uric acid; high sensitive C-reactive protein

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 4
• Pages: 687-691

Dates

published

2014

received

2013-05-20

revised

2014-01-23

accepted

2014-03-04

(unknown)

2014-10-07

Contributors

author

Şerafettin Demir

• Department of Cardiology, Adana State Hospital, Adana, Turkey

author

Gulhan Karakoyun

• Çukurova University, School of Medicine, Department of Biochemistry, Adana, Turkey

author

Mehmet Kanadasi

• Çukurova University, School of Medicine, Department of Cardiology, Adana, Turkey

References

• Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553.
• Anker SD, Leyva F, Poole-Wilson PA, Kox WJ, Stevenson JC, Coats AJ (1997) Relation between serum uric acid and lower limb blood flow in patients with chronic heart failure. Heart 78: 39-43.
• Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R (1977) Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 62: 597-607.
• Cao JJ, Thach C, Manolio TA, Psaty BM, Kuller LH, Chaves PH, Polak JF, Sutton-Tyrrell K, Herrington DM, Price TR, Cushman M (2003) C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study. Circulation 108: 166-170.
• Emmerson BT (1979) Atherosclerosis and urate metabolism. Aust N Z J Med 9: 451-454.
• Falsetti HL, Carrol RJ (1976) Coronary artery aneurysm. A review of the literature with a report of 11 new cases. Chest 69: 630-636
• Fang J, Alderman MH (2000) Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992: National Health and Nutrition Examination Survey. JAMA 283: 2404-2410.
• Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ (1987) Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316: 1371-1375.
• Hartnell GG, Parnell BM, Pridie RB (1985) Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients. Br Heart J 54: 392-395.
• Kato M, Hisatome I, Tomikura Y, Kotani K, Kinugawa T, Ogino K, Ishida K, Igawa O, Shigemasa C, Somers VK (2005) Status of endothelial dependent vasodilation in patients with hyperuricemia. Am J Cardiol 96: 1576-1578.
• Koşar F, Sincer İ, Aksoy Y, Topal E, Çehreli Ş (2005) Increased aortic stiffness in patients with coronary artery ectasia. Coron Artery Dis 16: 499-504.
• Leyva F, Anker S, Swan JW, Godsland IF, Wingrove CS, Chua TP, Stevenson JC, Coats AJ (1997) Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure. Eur Heart J 18: 858-865.
• Koga M, Murai J, Saito H, Mukai M, Kasayama S (2009) Serum glycated albumin, but not glycated haemoglobin, is low in relation to glycemia in hyperuricemic men. Acta Diabetol 47: 173-177.
• Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R (1976) Clinical significance of coronary artery ectasia. Am J Cardiol 37: 217-222
• Nagahama K, Iseki K, Inoue T, Touma T, Ikemiya Y, Takishita S (2004) Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa. Hypertens Res 27: 227-233.
• Ockene IS, Matthews CE, Rifai N, Ridker PM, Reed G, Stanek E (2001) Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults. Clin Chem 47: 444-450.
• Puig JG, Michán AD, Jiménez ML, Pérez de Ayala C, Mateos FA, Capitán CF, de Miguel E, Gijón JB (1991) Female gout. Clinical spectrum and uric acid metabolism. Arch Intern Med 151: 726-732.
• Puig JG, Ruilope LM (1999) Uric acid as a cardiovascular risk factor in arterial hypertension. J Hypertens 17: 869-872.
• Reaven GM (1994) Syndrome X: 6 years later. J Intern Med Suppl 736: 13-22.
• Seabra-Gomes R, Somerville J, Ross DN, Emanuel R, Parker DJ, Wong M (1974) Congenital coronary artery aneurysms. Br Heart J 36: 329-35.
• Sen N, Ozcan F, Uygur B, Aksu T, Akpinar I, Cay S, Cetin M, Sökmen E, Akçakoyun M, Maden O, Balbay Y, Erbay AR (2009) Elevated serum uric acid levels in patients with isolated coronary artery ectasia. Turk Kardiyol Dern Ars 37: 467-472.
• Stefanadis C1, Dernellis J, Tsiamis E, Stratos C, Diamantopoulos L, Michaelides A, Toutouzas P (2000) Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischemic heart disease. Eur Heart J 21: 390-396.
• Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, Mudd JG, Gosselin AJ (1983) Aneurysmal coronary artery disease. Circulation 67: 134-138.
• Torzewski J, Torzewski M, Bowyer DE, Fröhlich M, Koenig W, Waltenberger J, Fitzsimmons C, Hombach V (1998) C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol 18: 1386-1392.
• Torzewski M, Rist C, Mortensen RF, Zwaka TP, Bienek M, Waltenberger J (2000) C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb Vasc Biol 20: 2094-209.
• Vasquez-Vivar J, Santos AM, Junqueira VB, Augusto O (1996) Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acidderived free radicals. Biochem J 314: 869-876.