Cyclooxygenase pathways

• Authors: Jan Korbecki , Irena Baranowska-Bosiacka , Izabela Gutowska , Dariusz Chlubek
• Languages of publication: EN

Abstracts

EN

This review compiles the current knowledge on the effects of prostanoids - arachidonic acid metabolites - on their own synthesis, activity and degradation. Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A2 and prostaglandin I2 receptors. The questions of desensitization and internalization of receptors are discussed. The stages of the inflammatory response and tumor progression are analyzed against the background of the disruption of the synthesis of prostanoids. Special attention is given to the significance of 15-deoxy-Δ12,14-prostaglandin J2 in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. Ultimately, therapeutic approaches as used in various treatments are discussed in the light of the available knowledge.

Keywords

EN

cyclooxygenase; prostaglandin; 15-deoxy-Δ12,14-prostaglandin J2; receptor desensitization

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 4
• Pages: 639-649

Dates

published

2014

received

2013-11-20

revised

2014-06-16

accepted

2014-09-06

(unknown)

2014-10-23

Contributors

author

Jan Korbecki

• Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

author

Irena Baranowska-Bosiacka

• Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

author

Izabela Gutowska

• Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland

author

Dariusz Chlubek

• Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

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