Plasma citrulline level as a biomarker for cancer therapy-induced small bowel mucosal damage

• Authors: Justyna Barzał , Cezary Szczylik , Piotr Rzepecki , Małgorzata Jaworska , Elżbieta Anuszewska
• Languages of publication: EN

Abstracts

EN

Regimen-related mucosal toxicity is extremely common following cytotoxic chemotherapy and radiotherapy. Mucositis is as an important determinant of the inflammatory response and infectious complications in cancer treated patients. Most assessment scales for mucosal damage are focussed on oral mucositis, since it is easy to evaluate. Measuring gastrointestinal musocal damage objectively remains difficult because it cannot be seen directly or readily detected. One of potential non-invasive biomarkers of gastrointestinal mucosal damage is plasma citrulline level. Citrulline is an amino acid produced by small bowel enterocytes. Low concentration of free circulating citrulline signifies severe intestinal mucosal damage in humans with nonmalignant disorders, such as villous atrophy-associated diseases, short bowel syndrome, Crohn's disease, and is used in follow-up after small bowel transplantation. The plasma citrulline level is a reliable and objective biochemical marker of enterocyte mass and function in humans, and therefore can be used to monitor enterocyte toxicity resulting from chemotherapy and radiotherapy during anticancer therapy in patients with severely disturbed gut integrity.

Keywords

EN

biomarker; citrulline; mucositis; mucosal injury; toxicity

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 4
• Pages: 615-631

Dates

published

2014

received

2013-10-22

revised

2014-06-25

accepted

2014-10-07

(unknown)

2014-12-04

Contributors

author

Justyna Barzał

• Department of Oncology, Military Institute of Medicine, Warsaw, Poland

author

Cezary Szczylik

• Department of Oncology, Military Institute of Medicine, Warsaw, Poland

author

Piotr Rzepecki

• Department of Internal Medicine and Hematology with Bone Marrow Transplant Unit, Military Institute of Medicine, Warsaw, Poland

author

Małgorzata Jaworska

• Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, Warsaw, Poland

author

Elżbieta Anuszewska

• Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, Warsaw, Poland

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