The effect of Galleria mellonella hemolymph polypeptides on Legionella gormanii

• Authors: Elżbieta Chmiel , Marta Palusinska-Szysz , Agnieszka Zdybicka-Barabas , Małgorzata Cytryńska , Paweł Mak
• Languages of publication: EN

Abstracts

EN

Among Legionella species, which are recognized to be pathogenic for humans, L. gormanii is the second prevalent causative agent of community-acquired pneumonia after L. pneumophila. Anti-L. gormanii activity of Galleria mellonella hemolymph extract and apolipophorin III (apoLp-III) was examined. The extract and apoLp-III at the concentration 0.025 mg/ml caused 75% and 10% decrease of the bacteria survival rate, respectively. The apoLp-III-induced changes of the bacteria cell surface were analyzed for the first time by atomic force microscopy. Our studies demonstrated the powerful anti-Legionella effects of the insect defence polypeptides, which could be exploited in drugs design against these pathogens.

Keywords

EN

Legionella gormanii; Galleria mellonella; apolipophorin III; Atomic Force Microscopy

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 1
• Pages: 123-127

Dates

published

2014

received

2013-10-28

revised

2014-02-22

accepted

2014-02-25

(unknown)

2014-03-20

Contributors

author

Elżbieta Chmiel

• Department of Genetics and Microbiology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland

author

Marta Palusinska-Szysz

• Department of Genetics and Microbiology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland

author

Agnieszka Zdybicka-Barabas

• Department of Immunobiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Lublin, Poland

author

Małgorzata Cytryńska

• Department of Immunobiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Lublin, Poland

author

Paweł Mak

• Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

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