Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis

• Authors: Aleksandra Lisowska , Natalia Kobelska-Dubiel , Irena Jankowska , Joanna Pawłowska , Jerzy Moczko , Jarosław Walkowiak
• Languages of publication: EN

Abstracts

EN

Background & Aims: To date, no studies concerning the presence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis were published. Based upon characteristic of progressive familial intrahepatic cholestasis one can expect the coexistence of small intestinal bacterial overgrowth. The aim of the study was to assess the incidence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis. Methods: 26 patients aged 8 to 25 years with progressive familial intrahepatic cholestasis were included in the study. Molecular analysis of ABCB11 gene was performed in the vast majority of patients. In all patients Z-score for body weight and height, biochemical tests (bilirubin, bile acid concentration, fecal fat excretion) were assessed. In all patients hydrogen-methane breath test was performed. Results: On the basis of first hydrogen-methane breath test, diagnosis of small intestinal bacterial overgrowth was confirmed in 9 patients (35%), 5 patients (19%) had borderline results. The second breath test was performed in 10 patients: in 3 patients results were still positive and 2 patients had a borderline result. The third breath test was conducted in 2 patients and positive results were still observed. Statistical analysis did not reveal any significant correlations between clinical, biochemical and therapeutic parameters in patients with progressive familial intrahepatic cholestasis and coexistence of small intestinal bacterial overgrowth. Conclusions: Our results suggest that small intestinal bacterial overgrowth is frequent in patients with progressive familial intrahepatic cholestasis. Moreover, it seems that this condition has the tendency to persist or recur, despite the treatment.

Keywords

EN

small intestinal bacterial overgrowth; progressive familial intrahepatic cholestasis; hydrogen-methane breath test

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 1
• Pages: 103-107

Dates

published

2014

received

2013-10-09

revised

2014-01-20

accepted

2014-02-21

(unknown)

2014-03-17

Contributors

author

Aleksandra Lisowska

• Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland

author

Natalia Kobelska-Dubiel

• Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland

author

Irena Jankowska

• Department of Gastroenterology, Hepatology and Nutrition, Children's Memorial Health Institute, Warszawa, Poland

author

Joanna Pawłowska

• Department of Gastroenterology, Hepatology and Nutrition, Children's Memorial Health Institute, Warszawa, Poland

author

Jerzy Moczko

• Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań, Poland

author

Jarosław Walkowiak

• Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland

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