Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe

• Authors: Miroslava Pozgajova , Lubos Cipak , Anna Trakovicka
• Languages of publication: EN

Abstracts

EN

Chromosome segregation during meiosis is a complex process, which leads to production of four haploid gametes from two precursor cells. Reversible phosphorylation of proteins plays a crucial role in this process. The Schizosaccharomyces pombe Prp4 is an essential serine/threonine protein kinase, which belongs to the Clk/Sty family. To study the role of Prp4 in meiosis, we analysed chromosome segregation in a strain carrying conditional analog-sensitive allele of Prp4 protein kinase (prp4-as2). Our data show, that Prp4 protein kinase plays important role in chromosome segregation during meiosis, as revealed by enhanced missegregation of chromosomes in prp4-as2 mutant cells.

Keywords

EN

Prp4 protein kinase; S. pombe; meiosis; segregation; protein phosphorylation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2013
• Volume: 60
• Issue: 4
• Pages: 871-873

Dates

published

2013

received

2013-10-15

revised

2013-12-03

accepted

2013-12-18

Contributors

author

Miroslava Pozgajova

• Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia

author

Lubos Cipak

• Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia

author

Anna Trakovicka

• Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia

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