Studies on the formation of O/W nano-emulsions, by low-energy emulsification method, suitable for cosmeceutical applications

• Authors: Małgorzata Jaworska , Elżbieta Sikora , Michał Zielina , Jan Ogonowski
• Languages of publication: EN

Abstracts

EN

The formation of oil/water (O/W) nano-emulsions suitable for cosmeceutical application was studied. Nano-emulsions were prepared by using phase inversion composition (PIC) method, one of the low-energy emulsification methods. The process consist of stepwise water addition to oil/surfactant mixture, at T = 25°C. Caprylic/capric triglycerides (GTCC), propylene glycol dicaprylate/dicaprate (PC) and oleic acid (OA) were applied as an oil phase. Polysorbate 80 was used as the surfactant. Kinetic stability of the nano-emulsions was analyzed by measuring droplet size as a function of time for different oil/surfactant ratio. The particles size distribution was analyzed by means DLS measurement technique (Dynamic Light Scattering), using Zetasizer Nano ZS (Malvern Instruments, UK). One of triterpenoic acid, practically non-water soluble substance was selected as an active and incorporated into the stable formulation. The obtained results proved that the nanoemulsion NE-T80-GTCC-20:80 based on caprylic/capric triglycerides with the oil/surfactant ratio O/S = 2 0:80 and the droplet size r = 25 nm was the most stable one and additionally showed the highest solubilisation capacity for the triterpene.

Keywords

EN

nano-emulsions; crodamol GTCC; crodamol PC; oleic acid

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2013
• Volume: 60
• Issue: 4
• Pages: 779-782

Dates

published

2013

received

2013-10-15

revised

2013-12-04

accepted

2013-12-04

Contributors

author

Małgorzata Jaworska

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Elżbieta Sikora

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Michał Zielina

• Faculty of Environmental Engineering, Institute of Water Supply and Environmental Protection, Cracow University of Technology, Kraków, Poland

author

Jan Ogonowski

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

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