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2011 | 58 | 4 | 507-511

Article title

Secretion of proinflammatory cytokines by normal human melanocytes in response to lipopolysaccharide

Content

Title variants

Languages of publication

EN

Abstracts

EN
A large body of evidence suggests that epidermal melanocytes are an integral part of the skin immune system and can be considered immunocompetent cells. Recently, it has been reported that human melanocytes constitutively express Toll-like receptors and may be involved in the induction of several inflammatory cytokines. In the study the secretion of IL-1β, IL-6 and TNF-α by cultured normal melanocytes was investigated after stimulation with lipopolysaccharide. LPS increased the secretion of IL-1β in a dose-dependent manner. IL-1β stimulated release of IL-6 and TNF-α by melanocytes, whereas LPS activated production of TNF-α, but not of IL-6. These observations indicate that LPS can participate in the regulation of cytokine activity in normal human melanocytes and suggest that cytokines released by melanocytes could affect melanocytes themselves or/and other cells of the epidermis.

Year

Volume

58

Issue

4

Pages

507-511

Physical description

Dates

published
2011
received
2011-03-03
revised
2011-10-25
accepted
2011-11-28
(unknown)
2011-11-30

Contributors

author
  • Department of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland
  • Department of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv58p507kz
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