Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats

• Authors: Joanna Folwarczna , Barbara Nowińska , Leszek Śliwiński , Maria Pytlik , Urszula Cegieła , Anna Betka
• Languages of publication: EN

Abstracts

EN

Glucocorticoids and β2-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β2-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.

Keywords

EN

bone histomorphometry; bone mechanical properties; bone mineralization; fenoterol; prednisolone

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2011
• Volume: 58
• Issue: 3
• Pages: 313-319

Dates

published

2011

received

2010-11-10

revised

2011-07-01

accepted

2011-08-19

(unknown)

2011-08-31

Contributors

author

Joanna Folwarczna

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

author

Barbara Nowińska

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

author

Leszek Śliwiński

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

author

Maria Pytlik

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

author

Urszula Cegieła

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

author

Anna Betka

• Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland

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