Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results
2009 | 56 | 2 | 301-306

Article title

Lansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase

Content

Title variants

Languages of publication

EN

Abstracts

EN
Lansoprazole, a known H/K+-ATPase inhibitor, is currently used as a therapeutical option for the initial treatment of gastroesophageal reflux disease. Recently, lansoprazole has been found to be an inhibitor of cytosolic PHOSPHO1 (a phosphatase which hydrolyses phosphocholine and phosphoethanolamine), providing a possible therapeutical target to cure pathological mineralization. Since PHOSPHO1 is present inside matrix vesicles, we tested the effect of lansoprazole on matrix vesicles containing several key enzymes for the mineralization process including tissue-nonspecific alkaline phosphatase. We found that lansoprazole can inhibit in an uncompetitive manner tissue-nonspecific alkaline phosphatase. A Ki value of 1.74 ± 0.12 mM has been determined for the inhibition of tissue-nonspecific alkaline phosphatase by lansoprazole. Lansoprazole, currently used for treating gastroesophageal disease, by inhibiting PHOSPHO1 and tissue-nonspecific alkaline phosphatase could prevent hydroxyapatite-deposition disease and could serve as an adjunct treatment for osteoarthritis.

Year

Volume

56

Issue

2

Pages

301-306

Physical description

Dates

published
2009
received
2009-02-19
revised
2009-05-04
accepted
2009-06-10
(unknown)
2009-06-18

Contributors

  • Université de Lyon, INSA de Lyon, CPE Lyon, CNRS UMR 5246 ICBMS, Lyon, Villeurbanne Cedex, France
author
  • Université de Lyon, INSA de Lyon, CPE Lyon, CNRS UMR 5246 ICBMS, Lyon, Villeurbanne Cedex, France
  • Université de Lyon, INSA de Lyon, CPE Lyon, CNRS UMR 5246 ICBMS, Lyon, Villeurbanne Cedex, France

References

  • Ali SY (1985) Apatite-type crystal deposition in arthritic cartilage. Scan Electron Microsc 4: 1555-1566.
  • Anderson HC (1983) Calcific diseases, A concept. Arch Pathol Lab Med 107: 341-348.
  • Anderson HC (1988) Mechanisms of pathological calcification. Rheum Dis Clin North Am 14: 303-319.
  • Anderson HC (2007) The role of matrix vesicles in physiological and pathological calcification. Curr Opin Orthop 18: 428-433.
  • Anderson HC, Sipe JB, Hessle L, Dhanyamraju R, Atti E, Camacho NP (2004) Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol 164: 841-847.
  • Balcerzak M, Hamade E, Zhang L, Pikula S, Azzar G, Radisson J, Bandorowicz-Pikula J, Buchet R (2003) The roles of annexins and alkaline phosphatase in mineralization process. Acta Biochim Polon 50: 1019-1038.
  • Balcerzak M, Pikula S, Buchet R (2006) Phosphorylation-dependent phospholipase D activity of matrix vesicles. FEBS Lett 580: 5676-5680.
  • Balcerzak M, Radisson J, Azzar G, Farlay D, Boivin G, Pikula S, Buchet R (2007) A comparative analysis of strategies for isolation of matrix vesicles. Anal Biochem 361: 176-182.
  • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
  • Besancon M, Simon A, Sachs G, Shin JM (1997) Sites of reaction of the gastric H,K-ATPase with extracytoplasmic thiol reagents. J Biol Chem 272: 22438-22446.
  • Carroll GJ, Stuart RA, Armstrong JA, Breidahl BA, Laing BA (1991) Hydroxyapatite crystals are a frequent finding in osteoarthritis synovial fluid, but are not related to increased concentrations of keratan sulfate or interleukin 1 beta. J Rheumatol 18: 861-866.
  • Cyboron GW, Wuthier RE (1981) Purification and initial characterization of intrinsic membrane-bound alkaline phosphatase from chicken epiphyseal cartilage. J Biol Chem 256: 7262-7268.
  • Der G (2003) An overview of proton pump inhibitor. Gastroenterol Nurs 26: 182-190.
  • Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK (2002) The high prevalence of pathologic calcium crystals in preoperatives knees. J Rheumatol 29: 570-574.
  • DeVault KR, Castel DO (1999) Updated guidelines for the diagnosis and treatment of gastroeosophageal reflux disease. The Practise Parameters Committee of the American College of Gastroenterology. Am J Gastroenterol 94: 1434-1442.
  • Einhorn TA, Gordon SL, Siegel SA, Hummel CF, Avitable MJ, Carty RP (1985) Matrix vesicle enzymes in human osteoarthritis. J Orthop Res 3: 160-169.
  • Engstrom L (1961) Studies on calf-intestinal alkaline phosphatase. I. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme. Biochim Biophys Acta 52: 36-48.
  • Gordon GV, Villanueva T, Schumacher HR, Gohel V (1984) Autopsy study correlating degree of osteoarthritis, synovitis and evidence of articular calfication. J Rheumatol 11: 681-688.
  • Gremse DA (2001) Lansoprazole: pharmacokinetics, pharmacodynamics and clinical use. Expert Opin Pharmacother 2: 1663-1670.
  • Hsu HHT, Anderson HC (1996) Evidence of the presence of a specific ATPase responsible for ATP-initiated calcification by matrix vesicles isolated from cartilage and bone. J Biol Chem 271: 26383-26388.
  • Hsu HHT, Camacho NP, Anderson HC (1999) Further characterization of ATP-initiated calcification by matrix vesicles isolated from rachitic rat cartilage. Membrane perturbation by detergents and deposition of calcium pyrophosphate by rachitic matrix vesicles. Biochim Biophys Acta 1416: 320-332.
  • Kirsch T (2007) Physiological and pathological calcification: a complex multifactorial process. Curr Opin Orthop 18: 425-427.
  • Kivioja A, Linnosmaa I, Vehviläinen A, Vohlonen L (2004) Cost-minimization analysis of treatment of gastroesophageal reflux disease: implications of varying holding time on coclusions. Eur J Pharm Sci 21: 171-178.
  • McGill PE (1976) Levamisole in rheumatoid arthritis. Lancet 1: 149.
  • Miller B, Demerieux P, Spinivasan R, Clemments P, Fan P, Levy J, Paulus HE (1980) Double-blind placebo-controlled cross-over evaluation of levamisole in rheumatoid arthritis. Arthritis Rheum 23: 172-182.
  • Nalbant S, Martinez JA, Kitumnuaypong T, Clayburne G, Sieck M, Schumacher Jr HR (2003) Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies. Osteoarthritis Cartilage 11: 50-54.
  • Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millán JL (2007) Novel inhibitors of alkaline phosphatase suppress vascular smooth cell calcification. J Bone Miner Res 22: 1700-1710.
  • Register TC, Wuthier RE (1985) Effect of pyrophosphate and two biphosphonate on 45Ca and 32Pi uptake and mineralization by matrix vesicle-enriched fractions and by hydroxyapatite. Bone 6: 307-312.
  • Register TC, McLean FM, Low MG, Wuthier RE (1986) Roles of alkaline phosphatase and labile internal mineral in matrix vesicle-mediated calcification. J Biol Chem 261: 9354-9360.
  • Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C (2004) Human PHOSPHO1 displays high specific phosphoethanolamine and phosphocholine phosphatase activity. Biochem J 382: 59-65.
  • Roberts SSJ, Stewart AJ, Schmid R, Blindauer CA, Bond SR, Sadler PJ, Farquharson C (2005) Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Biochim Biophys Acta 1752: 73-82.
  • Roberts SJ, Stewart AJ, Seawright E, Davey E, Fleming MG, Farquharson C (2006) The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Bone 39: 1000-1007.
  • Roberts SJ, Narisawa S, Harmey D, Milan JL, Farquharson C (2007) Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. J Bone Miner Res 22: 617-627.
  • Shi S, Klotz U (2008) Proton pump inhibitors: an update of their clinical use and pharmacokinetics. Eur J Clin Pharmacol 64: 935-951.
  • Sidique S, Ardecky R, Su Y, Narisawa S, Brown B, Millan JL, Sergienko E, Cosford DP (2009) Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Bioorg Med Chem Lett 19: 222-225.
  • Wu LN, Genge BR, Dunkelberger DG, LeGeros RZ, Concannon B, Wuthier R (1997) Physicochemical characterization of the nucleational core of matrix vesicles. J Biol Chem 272: 4404-4411.
  • Zhang L, Balcerzak M, Radisson J, Thouverey C, Pikula S, Azzar G, Buchet R (2005) Phosphodiesterase activity of alkaline phosphatase in ATP-initiated Ca2+2+and phosphate deposition in isolated chicken matrix vesicles. J Biol Chem 280: 37289-37296.

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv56p301kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.