Identification of 2-[2-nitro-4-(trifluoromethyl)benzoyl]- cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of 1H and 19F NMR spectroscopy

• Authors: Przemysław Szczeciński , Diana Lamparska , Adam Gryff-Keller , Wanda Gradowska
• Languages of publication: EN

Abstracts

EN

Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by 1H and 19F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as well as a few other unidentified compounds containing CF3 group was documented.

Keywords

EN

tyrosinemia; NMR; NTBC metabolites

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2008
• Volume: 55
• Issue: 4
• Pages: 749-752

Dates

published

2008

received

2008-07-07

revised

2008-10-14

accepted

2008-11-21

(unknown)

2008-11-28

Contributors

author

Przemysław Szczeciński

• Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland

author

Diana Lamparska

• Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland

author

Adam Gryff-Keller

• Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland

author

Wanda Gradowska

• Department of Biochemistry and Experimental Medicine, Children's Memorial Health Institute, Warszawa, Poland

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