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Number of results
2007 | 54 | 4 | 703-715

Article title

Hepatitis C - new developments in the studies of the viral life cycle

Content

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EN

Abstracts

EN
Hepatitis C virus (HCV) is a causative agent of chronic liver disease leading to cirrhosis, liver failure and hepatocellular carcinoma. The prevalence of HCV is estimated as 3% of the world population and the virus is a major public health problem all over the world. For over 16 years, since HCV had been discovered, studies of the mechanisms of the viral life cycle and virus-host interactions have been hampered by the lack of a cell culture system allowing the virus to be grown in laboratory conditions. However, in recent years some new model systems to study HCV have been developed. The major breakthrough of the last two years was the cell culture system for maintaining the virus in an adapted hepatocyte-derived cell line. This review describes the techniques and applications of most of the in vitro systems and animal models currently used for working with hepatitis C virus.

Year

Volume

54

Issue

4

Pages

703-715

Physical description

Dates

published
2007
received
2007-02-12
revised
2007-05-29
accepted
2007-09-17
(unknown)
2007-10-25

Contributors

  • Department of Molecular Virology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
  • Department of Molecular Virology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland

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bwmeta1.element.bwnjournal-article-abpv54p703kz
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