Synthesis of a quaternary polyprenyl ammonium salt

• Authors: Olga V Sizova , Natalia S Utkina , Nadezhda A Kalinchuk , Leonid L Danilov , Sergey D Maltsev
• Languages of publication: EN

Abstracts

EN

Reaction of primary C55-allylic alcohol moraprenol (WT3C7-9-OH, a polyprenol from mulberry leaves) with triethylamine in the presence of phosphorus oxychloride leads to a quaternary ammonium chloride with a good yield (72%) and high cis-stereoselectivity of the terminal isoprene unit. Cationic polyprenyl derivatives may be useful for transfection and immunological studies.

Keywords

EN

polyprenol; quaternary ammonium salts; cationic lipids

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2007
• Volume: 54
• Issue: 4
• Pages: 869-872

Dates

published

2007

received

2007-08-08

accepted

2007-10-11

revised

2007-10-11

(unknown)

2007-12-11

Contributors

author

Olga V Sizova

• Kochetkov Laboratory of Carbohydrate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

author

Natalia S Utkina

• Kochetkov Laboratory of Carbohydrate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

author

Nadezhda A Kalinchuk

• Kochetkov Laboratory of Carbohydrate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

author

Leonid L Danilov

• Kochetkov Laboratory of Carbohydrate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

author

Sergey D Maltsev

• Kochetkov Laboratory of Carbohydrate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

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