Gamijeonssibaekchulsan regulates mast cell-mediated anaphylactic reaction

• Authors: Phil Dong Moon , Hye Young Shin , Ho Jeong Na , Hyun Ja Jeong , Su Jin Kim , Jae Young Um , Rae Kil Park , Hyung Min Kim , Seung Heon Hong
• Languages of publication: EN

Abstracts

EN

Gamijeonssibaekchulsan (GJBS) is a typical Oriental medicine prescription which has been used in Korea for the treatment of allergic diseases and the development of physical strength. However, as yet there is no clear explanation of how GJBS affects the anaphylactic reaction and the immune function. In the present study murine models and MOLT-4 cells, a T cell line, were used to investigate these effects. Compound 48/80-induced systemic anaphylactic shock and ear swelling response were firstly analyzed. We also assayed histamine release and passive cutaneous anaphylaxis (PCA) in mice and cytokine productions in MOLT-4 cells. GJBS significantly inhibits compound 48/80-induced systemic anaphylactic shock and ear swelling response. GJBS also inhibits histamine release from rat peritoneal mast cells induced by compound 48/80. PCA activated by anti-dinitrophenyl immunoglobulin E is attenuated by GJBS. However, GJBS dose not affect the production of interferon-γ, interleukin (IL)-2, and IL-4 in MOLT-4 cells. These results indicate that GJBS has a potential regulatory effect on allergic reactions that are mediated by mast cells.

Keywords

EN

histamine; passive cutaneous anaphylaxis; gamijeonssibaekchulsan; MOLT-4 cells

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2007
• Volume: 54
• Issue: 2
• Pages: 349-355

Dates

published

2007

received

2007-01-10

revised

2007-05-08

accepted

2007-05-22

(unknown)

2007-06-04

Contributors

author

Phil Dong Moon

• College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

author

Hye Young Shin

• College of Pharmacy, Woosuk University, Wanju, Jeonbuk, Republic of Korea

author

Ho Jeong Na

• College of Pharmacy, Woosuk University, Wanju, Jeonbuk, Republic of Korea

author

Hyun Ja Jeong

• College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

author

Su Jin Kim

• College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

author

Jae Young Um

• College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

author

Rae Kil Park

• VestibuloCochlear Research Center of Wonkwang University, Iksan, Jeonbuk, Republic of Korea

author

Hyung Min Kim

• College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

author

Seung Heon Hong

• College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Republic of Korea

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