Bacterial chromosome segregation.

• Authors: Aneta A Bartosik , Grażyna Jagura-Burdzy
• Languages of publication: EN

Abstracts

EN

In most bacteria two vital processes of the cell cycle: DNA replication and chromosome segregation overlap temporally. The action of replication machinery in a fixed location in the cell leads to the duplication of oriC regions, their rapid separation to the opposite halves of the cell and the duplicated chromosomes gradually moving to the same locations prior to cell division. Numerous proteins are implicated in co-replicational DNA segregation and they will be characterized in this review. The proteins SeqA, SMC/MukB, MinCDE, MreB/Mbl, RacA, FtsK/SpoIIIE playing different roles in bacterial cells are also involved in chromosome segregation. The chromosomally encoded ParAB homologs of active partitioning proteins of low-copy number plasmids are also players, not always indispensable, in the segregation of bacterial chromosomes.

Keywords

EN

proteins engaged in chromosome partitioning; sister cohesion model; bacterial cell cycle; factory model; chromosome replication and segregation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2005
• Volume: 52
• Issue: 1
• Pages: 1-34

Dates

published

2005

received

2005-01-25

accepted

2005-02-28

Contributors

author

Aneta A Bartosik

• Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

author

Grażyna Jagura-Burdzy

• Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

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