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2004 | 51 | 3 | 815-824

Article title

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

Content

Title variants

Languages of publication

EN

Abstracts

EN
The redox status of plasma thiols can be a diagnostic indicator of different pathological states. The aim of this study was to identify the age dependent changes in the plasma levels of total, free and protein bound glutathione, cysteine and homocysteine. The determination was conducted in plasma of three groups of rats: 1) young (3-month-old), 2) middle aged (19-month-old), and 3) old (31-month-old). Total levels of glutathione, cysteine and homocysteine and their respective free and protein-bound fractions decreased with age. The only exception was a rise in free homocysteine concentration in the middle group, which indicates a different pattern of transformations of this thiol in plasma. The drop in the level of protein-bound thiols suggests that the antioxidant capacity of plasma diminishes with age, which, consequently, leads to impaired protection of -SH groups through irreversible oxidation. The plasma sulfane sulfur level also declines with age, which means that aging is accompanied by inhibition of anaerobic sulfur metabolism.

Keywords

Year

Volume

51

Issue

3

Pages

815-824

Physical description

Dates

published
2004
received
2003-11-19
revised
2004-04-01
accepted
2004-05-17

Contributors

  • Institute of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland
  • Department of Environmental Chemistry, University of Łódź, Łódź, Poland
  • Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland
author
  • Department of Environmental Chemistry, University of Łódź, Łódź, Poland
author
  • Institute of Medical Biochemistry, Collegium Medicum, Jagiellonian University; Kraków, Kraków, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv51i3p815kz
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