Preliminary studies of phthalocyanine sensitizers incorporated into human leukemia cells from two cell-lines.

• Authors: Krzysztof Wiktorowicz , Justyna Cofta , Alina Dudkowiak , Aneta Waszkowiak , Danuta Frąckowiak
• Languages of publication: EN

Abstracts

EN

Three phthalocyanine dyes-sensitizers were incorporated into two types of human T leukemia cells from two cell-lines: CCRF and MOLT 4. The efficiency of the dye incorporation into cells and photochemical properties of stained cells were investigated using fluorescence spectroscopy. The dyes exhibited different properties in each of the two cell-lines. Small differences in cell membrane properties have a strong influence on the efficiency of dye incorporation and on the course of photodynamic reaction. It is suggested that, for a given patient, an optimal dye-sensitizer should be established before photodynamic treatment.

Keywords

EN

MOLT 4 cells; fluorescence; photodynamic therapy; phthalocyanine; CCRF cells

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2004
• Volume: 51
• Issue: 3
• Pages: 703-710

Dates

published

2004

received

2003-06-26

revised

2004-01-13

accepted

2004-04-23

Contributors

author

Krzysztof Wiktorowicz

• Department of Biology and Environmental Sciences, K. Marcinkowski University of Medical Sciences, Poznań, Poland

author

Justyna Cofta

• Department of Biology and Environmental Sciences, K. Marcinkowski University of Medical Sciences, Poznań, Poland

author

Alina Dudkowiak

• Institute of Physics, Poznań University of Technology, Poznań, Poland

author

Aneta Waszkowiak

• Institute of Physics, Poznań University of Technology, Poznań, Poland

author

Danuta Frąckowiak

• Institute of Physics, Poznań University of Technology, Poznań, Poland

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