Role of the mitochondrial ATP-sensitive K+ channels in cardioprotection.

• Authors: Hossein Ardehali
• Languages of publication: EN

Abstracts

EN

The mitochondrial ATP-sensitive K+ (mitoKATP) channel was discovered more than a decade ago. Since then, several pharmacological studies have identified agents that target this channel some of which selectively target mitoKATP. These and other studies have also suggested that mitoKATP plays a key role in the process of ischemic preconditioning (IPC) and prevention of apoptosis. The mechanism by which mitoKATP exerts its protective effects is unclear, however, changes in mitochondrial Ca2+ uptake and levels of reactive oxygen species, and mitochondrial matrix swelling are believed to be involved. Despite major advances, several important issues regarding mitoKATP remain unanswered. These questions include, but are not limited to: the molecular structure of mitoKATP, the downstream and upstream mechanisms that leads to IPC and cell death, and the pharmacological profile of the channel. This review attempts to provide an up-to-date overview of the role of mitoKATP in cardioprotection.

Keywords

EN

diazoxide; mitochondria; apoptosis; potassium channel; ischemic preconditioning

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2004
• Volume: 51
• Issue: 2
• Pages: 379-390

Dates

published

2004

received

2004-04-30

accepted

2004-05-07

Contributors

author

Hossein Ardehali

• ivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, U.S.A.

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