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2004 | 51 | 2 | 373-378

Article title

RNA modulation, repair and remodeling by splice switching oligonucleotides.

Content

Title variants

Languages of publication

EN

Abstracts

EN
Targeting splicing by antisense oligonucleotides allows RNA modifications that are not possible with RNA interference or other antisense techniques that destine the RNA for destruction. By changing the ratio of naturally occurring splice variants the expression of mRNA is modulated. By preventing the use of an aberrant splice site created by a mutation and enforcing re-selection of correct splice sites the RNA is repaired. Antisense induced skipping of the exon that carries a nonsense mutation remodels the mRNA and restores the reading frame of the defective protein. All of the above approaches have clinical applications. Modulation of splice variants is particularly important since close to 60% of all genes code for alternatively spliced pre-mRNA.

Year

Volume

51

Issue

2

Pages

373-378

Physical description

Dates

published
2004
received
2004-05-07
accepted
2004-05-20

Contributors

author
  • Department of Pharmacology, Medicine, Curriculum in Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, U.S.A.
  • Department of Pharmacology, Medicine, Curriculum in Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, U.S.A.
author
  • Department of Pharmacology, Medicine, Curriculum in Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, U.S.A.

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv51i2p373kz
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