PDZ domains - common players in the cell signaling.

• Authors: Filip Jeleń , Arkadiusz Oleksy , Katarzyna Śmietana , Jacek Otlewski
• Languages of publication: EN

Abstracts

EN

PDZ domains are ubiquitous protein interaction modules that play a key role in cellular signaling. Their binding specificity involves recognition of the carboxyl-terminus of various proteins, often belonging to receptor and ion channel families. PDZ domains also mediate more complicated molecular networks through PDZ-PDZ interactions, recognition of internal protein sequences or phosphatidylinositol moieties. The domains often form a tandem of multiple copies, but equally often such tandems or single PDZ domain occur in combination with other signaling domains (for example SH3, DH/PH, GUK, LIM, CaMK). Common occurrence of PDZ domains in Metazoans strongly suggests that their evolutionary appearance results from the complication of signaling mechanisms in multicellular organisms. Here, we focus on their structure, specificity and role in signaling pathways.

Keywords

EN

PDZ domain; module; protein-protein interaction; signaling

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2003
• Volume: 50
• Issue: 4
• Pages: 985-1017

Dates

published

2003

received

2003-06-14

revised

2003-10-06

accepted

2003-10-09

Contributors

author

Filip Jeleń

• Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland

author

Arkadiusz Oleksy

• Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland

author

Katarzyna Śmietana

• Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland

author

Jacek Otlewski

• Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland

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