The structure of the Ca2+-ATPase of sarcoplasmic reticulum.

• Authors: Anthony N Martonosi , Slawomir Pikula
• Languages of publication: EN

Abstracts

EN

In this article the morphology of sarcoplasmic reticulum, classification of Ca2+-ATPase (SERCA) isoenzymes presented in this membrane system, as well as their topology will be reviewed. The focus is on the structure and interactions of Ca2+-ATPase determined by electron and X-ray crystallography, lamellar X-ray and neutron diffraction analysis of the profile structure of Ca2+-ATPase in sarcoplasmic reticulum multilayers. In addition, targeting of the Ca2+-ATPase to the sarcoplasmic reticulum is discussed.

Keywords

EN

calcium pump; calcium homeostasis; calcium transport; skeletal and cardiac muscles; sarcoplasmic reticulum; excitation-contraction coupling

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2003
• Volume: 50
• Issue: 2
• Pages: 337-365

Dates

published

2003

received

2003-05-30

accepted

2003-06-02

Contributors

author

Anthony N Martonosi

• tate University of New York, Upstate Medical University, College of Graduate Studies, Syracuse, New York, U.S.A.

author

Slawomir Pikula

• M. Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland

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