Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits.

• Authors: Anna Gumieniczek , Hanna Hopkała , Zbigniew Wójtowicz , Justyna Nikołajuk
• Languages of publication: EN

Abstracts

EN

The present study was designed to evaluate the oxidative stress-related parameters in alloxan-induced diabetes in rabbits. After 3, 6, 12 and 24 weeks of hyperglycaemia the enzymatic and non-enzymatic factors were measured in heart tissue of diabetic and control groups. Superoxide dismutase and glutathione peroxidase activities and the contents of total sulfhydryl compounds significantly increased at all time intervals. Catalase activity increased initially (after 3 and 6 weeks), decreased after 12 weeks and increased again at the 24th week of the experiment. Glutathione reductase activity increased initially (at 3rd week), decreased below control level after 6 and 12 weeks, then increased again. Ascorbic acid concentration decreased after 3 and 6 weeks, and increased at the 12th and 24th weeks. The level of lipid peroxidation products was reduced after 3, 6 and 12 weeks of the experiment. After 24 weeks it was significantly elevated. These data suggest that hyperglycaemia induces oxidative stress in the heart but the defense mechanisms in the heart tissue are fairly efficacious against oxidative injury.

Keywords

EN

heart muscle tissue; antioxidant status; alloxan-induced diabetes; lipid peroxidation; oxidative stress

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 2
• Pages: 529-535

Dates

published

2002

received

2001-10-11

revised

2002-03-20

accepted

2002-05-09

Contributors

author

Anna Gumieniczek

• Department of Medicinal Chemistry, Medical University of Lublin, Lublin, Poland

author

Hanna Hopkała

• Department of Medicinal Chemistry, Medical University of Lublin, Lublin, Poland

author

Zbigniew Wójtowicz

• Department of Human Physiological Anatomy, Medical University of Lublin, Lublin, Poland

author

Justyna Nikołajuk

• Department of Medicinal Chemistry, Medical University of Lublin, Lublin, Poland

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