Collagen of umbilical cord vein and its alterations in pre-eclampsia.

• Authors: Lech Romanowicz , Stefan Jaworski
• Languages of publication: EN

Abstracts

EN

The state of the vascular system of the mother and of placenta is known to exert a great influence on intrauterinal development of the fetus. Pre-eclampsia is the most common pathological syndrome connected with pregnancy. Since collagen is one of the main constituents of the vessel wall a comparison was made with collagen content and its molecular polymorphism in umbilical cord veins of newborns from healthy and pre-eclamptic mothers. It was found that umbilical cord veins of newborns from mothers with pre-eclampsia contained 18% less collagen than those of the newborns from normal pregnancies. This decrease was accompanied by a slight decrease of collagen solubility, but all its types (I, III, IV, V and VI) were present. However, the umbilical vein wall of newborns from mothers with pre-eclampsia contained relatively less of type I and more of type III collagen than the normal umbilical cord. These differences may be connected with a disturbance of blood flow in fetus of a woman with pre-eclampsia.

Keywords

EN

collagen; umbilical cord vein; pre-eclampsia

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 2
• Pages: 451-458

Dates

published

2002

received

2001-07-25

revised

2002-04-24

accepted

2002-05-10

Contributors

author

Lech Romanowicz

• Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland

author

Stefan Jaworski

• Department of Gynecology, Medical Academy of Białystok, Białystok, Poland

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