Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae.

• Authors: Agnieszka Białkowska , Anna Kurlandzka
• Languages of publication: EN

Abstracts

EN

The protein encoded by the IRR1/SCC3 gene is an element of the cohesin complex of Saccharomyces cerevisiae, responsible for establishing and maintaining sister chromatid cohesion during mitotic cell division. We noticed previously that lowering the level of expression of IRR1/SCC3 affects colony formation on solid support. Here we describe two dosage suppressors (IST2, NOG2) overcoming the inability to form colonies of an Irr1p-deficient strain. Ist2 is probably involved in osmotolerance, Nog2p is a putative GTPase required for 60S ribosomal subunit maturation, but may also participate in mRNA splicing.

Keywords

EN

60S ribosomal subunit; sister chromatid cohesion; salt tolerance

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2002
• Volume: 49
• Issue: 2
• Pages: 421-425

Dates

published

2002

received

2002-03-10

revised

2002-04-23

accepted

2002-05-29

Contributors

author

Agnieszka Białkowska

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

author

Anna Kurlandzka

• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

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