Synthesis and application of chiral triazine condensing reagents prepared from esters of amino acids.

• Authors: Zbigniew J Kamiński , Krzysztof J Zając , Konrad Jastrząbek
• Languages of publication: EN

Abstracts

EN

Treatment of cyanuric chloride with chiral amines or esters of chiral amino acids gave chiral 2,4-dichloro-6-alkylamino-1,3,5-triazines (2-5) in 49-69% yield, which were found useful as coupling reagents. Enantioselective activation and enantioselective aminolysis in the presence of 2-5 was observed.

Keywords

EN

enantioselective reagent; coupling reagent; chiral triazines; peptide synthesis

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1143-1146

Dates

published

2001

received

2001-09-26

accepted

2001-11-20

Contributors

author

Zbigniew J Kamiński

• Institute of Organic Chemistry, Technical University of Lodz, 90-924 Lodz, Poland

author

Krzysztof J Zając

• Institute of Organic Chemistry, Technical University of Lodz, 90-924 Lodz, Poland

author

Konrad Jastrząbek

• Institute of Organic Chemistry, Technical University of Lodz, 90-924 Lodz, Poland

References

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• 2. Kamiński, Z.J., Kolesińska, B., Markowicz, S.W. & Pokrzeptowicz, K. (1999) Pol. J. Chem. 73, 1965-1968.
• 3. Kamiński, Z.J., Kolesińska, B., Kamińska, J.E. & Góra, J. (2001) J. Org. Chem 66, 6276-6281.
• 4. Masala, S. & Taddei, M. (1999) Org. Lett 1, 1355-1357.
• 5. Kamiński, Z.J. (2000) Biopolymers 55, 140-165.