Mass spectrometric analysis of head-to-tail connected cyclic peptides.

• Authors: Marcus Macht , Matthias Pelzing , Petra Palloch , Volker Sauerland , Jürgen Volz
• Languages of publication: EN

Abstracts

EN

Tandem mass spectrometry is an extremly useful tool for high sensitive sequence identification of peptides. In the case of cyclic peptides fragmentation can easily be performed for sequence analysis. However, analysis is usually tedious due to the lack of a defined beginning and end of the sequence. Since cyclic peptides are a highly interesting class of compounds especially for the pharmaceutical industry, ways have to be found to identify their structures. In this work we demonstrate how software and dedicated analytical strategies can be used for detailed analysis of these substances.

Keywords

EN

electrospray; post source decay; MALDI; mass spectrometry; peptide sequencing

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2001
• Volume: 48
• Issue: 4
• Pages: 1109-1112

Dates

published

2001

received

2001-09-19

accepted

2001-11-10

Contributors

author

Marcus Macht

• Bruker Saxonia Analytik GmbH, Leipzig, Germany

author

Matthias Pelzing

• Bruker Saxonia Analytik GmbH, Leipzig, Germany

author

Petra Palloch

• Bruker Saxonia Analytik GmbH, Leipzig, Germany

author

Volker Sauerland

• Bruker Saxonia Analytik GmbH, Leipzig, Germany

author

Jürgen Volz

• Bruker Saxonia Analytik GmbH, Leipzig, Germany

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