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2001 | 48 | 4 | 1077-1084

Article title

Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer.

Content

Title variants

Languages of publication

EN

Abstracts

EN
We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.

Year

Volume

48

Issue

4

Pages

1077-1084

Physical description

Dates

published
2001
received
2001-10-17
revised
2001-11-22
accepted
2001-11-26

Contributors

  • Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
  • Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
  • Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
  • Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland

References

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  • 2. Ji, W.R., Castellino, F.J., Chang, Y., Deford, M.E., Gray, H., Villarreal, X., Kondri, M.E., Marti, D.N., Llinás, M., Schaller, J., Kramer, R.A. & Trail, P.A. (1998) Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis. FASEB J. 12, 1731-1738.
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv48i4p1077kz
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