Selectin glycoprotein ligands.

• Authors: Iwona Żak , Ewelina Lewandowska , Wojciech Gnyp
• Languages of publication: EN

Abstracts

EN

Lectin selectins and their counter-receptors participate in discontinuous cell-cell interactions concurrent with leukocyte tethering and rolling on endothelium, which, in consequence, leads to leukocyte penetration to lymphatic organs and generation of inflammation sites. Counter-receptors are glycoproteins in which carbohydrate units, the direct selectin ligands, are built into the polypeptide framework. In this review, the distribution, structure and function of the main ligands and counter-receptors for P-, L- and E-selectins known so far, have been discussed. The common biosynthetic pathway of sialyl-Lewis x and sulpho-sialyl-Lewis x determinants of selectin ligands has been described.

Keywords

EN

sulpho-sialyl Lewis(x) determinant; sialyl-Lewis(x) determinant; selectin counter-receptor; selectin ligands

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 2
• Pages: 393-412

Dates

published

2000

received

1999-02-2

revised

2000-03-23

accepted

2000-05-10

Contributors

author

Iwona Żak

• Department of Chemistry and General Biochemistry, Silesian Medical Academy, Katowice, Poland

author

Ewelina Lewandowska

• Department of Chemistry and General Biochemistry, Silesian Medical Academy, Katowice, Poland

author

Wojciech Gnyp

• Department of Chemistry and General Biochemistry, Silesian Medical Academy, Katowice, Poland

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