Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro.

• Authors: Tomasz Kryczka , Paweł Grieb , Maciej Bero , Janusz Kasperczyk , Piotr Dobrzynski
• Languages of publication: EN

Abstracts

EN

We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a relatively constant release of adenosine for over four weeks, resulting in micromolar concentrations of nucleoside in the eluate. This points to the neccessity of further development of polymers of this types as intracerebral nucleoside delivery systems for local treatment of brain tumors.

Keywords

EN

biodegradable polymers; adenosine

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 1
• Pages: 59-64

Dates

published

2000

received

1999-10-25

Contributors

author

Tomasz Kryczka

• Medical Research Center, Polish Academy of Sciences, 02-106, Warszawa, Poland

author

Paweł Grieb

• Medical Research Center, Polish Academy of Sciences, 02-106, Warszawa, Poland

author

Maciej Bero

• Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

author

Janusz Kasperczyk

• Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

author

Piotr Dobrzynski

• Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

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