Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

• Authors: Ulf Vogt , Bogdan Falkiewicz , Krzysztof Bielawski , Ulrich Bosse , Claus M Schlotter
• Languages of publication: EN

Abstracts

EN

A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.

Keywords

EN

cultured tumor cells; antitumor drug screening assays; oncogenes; ovarian cancer; antineoplastic agents

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2000
• Volume: 47
• Issue: 1
• Pages: 157-164

Dates

published

2000

received

1999-10-25

Contributors

author

Ulf Vogt

• European Laboratory Association Section Ibbenbüren, Ibbenbüren, Germany

author

Bogdan Falkiewicz

• Faculty of Chemistry, Univeristy of Gdańsk, Gdańsk, Poland

author

Krzysztof Bielawski

• Molecular Diagnostics Division, Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland

author

Ulrich Bosse

• Institute of Pathology, Osnabrück, Germany

author

Claus M Schlotter

• Department of Obstetrics/Gynecology, St. Elisabeth Hospital, Ibbenbüren, Germany

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