Greener, facile and ultrasound assisted synthesis of 1,2,3-triazole via CuAAC of 2-(azidomethyl)-1H-benzo[d]imidazole and alkynes and their evaluation of antimicrobial activity

• Authors: Vimalkumar H. Kapupara , Prakash L. Kalavadiya , Dinesh G. Gojiya , Nilesh D. Parmar , Hitendra S. Joshi
• Languages of publication: EN

Abstracts

EN

An expeditious room temperature protocol for the synthesis of 1,4-disubstituted 1H-1,2,3-triazol-1-yl)methyl)-1H-benzo[d]imidazole from [3+2] cyclization by using 1H-benzo[d]imidazole azide and various substituted terminal alkynes and copper(I) as a catalyst. This synthetic approach has been various prominent features such as fewer reaction steps, Good Yield, simple reaction condition and no any further purification required. Characterizations of all the synthesized compounds were done by various spectroscopic techniques like FT-IR, NMR and Mass spectrometry. All the synthesized targeted compounds were screened and evaluated for their antimicrobial activities.

Keywords

EN

1; 1H-benzo[d]imidazole azide; 2; 3-triazol-1-yl)methyl)-1H-benzo[d]imidazole; 3-triazole via CuAAC; 4-disubstituted 1H-1; alkynes; antimicrobial; copper(I) catalyst

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World Scientific News
• Year: 2019
• Volume: 119
• Pages: 139-167

Contributors

author

Vimalkumar H. Kapupara

• Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India

author

Prakash L. Kalavadiya

• Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India

author

Dinesh G. Gojiya

• Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India

author

Nilesh D. Parmar

• Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India

author

Hitendra S. Joshi

• Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India

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• Document Type: article