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2014 | 19 | 111-117
Article title

ADSORPTION STUDIES OF KETOCONAZOLE WITH CHITOSAN

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Abstracts
EN
Combinations of polymers and biopolymers of biologically active compounds in the last period have been the subject of intensive research. The active substance linked to a polymer often has a modified function and sometimes no action. On the other hand, the use of unsuitable polymers may result in a type of mismatch of drug-polymer. The aim of the study was to examine whether the active substance ketoconazole causes incompatibility with dietary supplements containing chitosan. Antifungal drug adsorption phenomenon was investigated by the static method in the concentration range of the single dose using a pharmaceutical model of the gastrointestinal tract. The test results show that the antifungal agent is adsorbed onto the chitosan in the pH ranges used, and the binding ability of the chitosan depends on the variety, or indirectly from the reaction environment. It was observed that the average sorption, depending on the variety of chitosan, was located in the limit from 94% to 100%. The increase of the size of the adsorption of anti-inflammatory drugs on the polymer with increasing pH from 7.6 to 8.0 can be explained by the swelling properties of chitosan, which grow with increasing pH of the environment in the direction of alkaline pH. Thus, the specific surface area and polymer sorption capacity is increased. Based on the above considerations, it can be concluded that, between the test drug and the polymer, there is antagonistic interaction involving the adsorption of the drug of this group on a polymer which is chitosan.
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Volume
19
Pages
111-117
Physical description
References
  • 1. Dzierżanowska D.; (2002) Antybiotykoterapia praktyczna. Wyd. 3. Bielsko-Biała: A-medica Press, 112.
  • 2. Meler J., Pluta J., Ulanski P. the and Krotkiewski M.; (2003) Fat- the binding capacity of ninths - the modified and modified chitosans. In: Progress on Chemistry and Application of Chitin and its Derivatives. Vol. IX (ed.: H. Struszczyk), Polish Chitin Society, Lodz, pp. 129-136.
  • 3. Filipkowska, U, Klimiuk, E, Grabowski, S, Siedlecka, E.; (2002) Adsorption of reactive dyes by modified chitin from aqueous solutions. Pol. J. Environ. Stud.11, 315-323,
  • 4. Meler J., Pluta J.; (2004) The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical patterne lof digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, 131-137.
  • 5. Grimling B., Meler J., Pluta J.; (2009) Study of interaction of gastrointestinal agents in the presence of cytoprotective drug including bismuth. In: Pierwiastki, środowisko i życie człowieka, ed. Kazimierz Pasternak, Polskie Towarzystwo Magnezologiczne, 65-74.
  • 6. Meler J., Grimling B., Pluta J.; (2010) Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium. J. Elementol.15, 141-147.
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  • 8. Meler J.; (2009) The effect of physicochemical factors on absorption properties of certain spasmolytics in the presence of dietary supplements containing chitosan. Progress on Chemistry and Application of Chitin and Its Derivatives 14, 133-1435.
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article
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YADDA identifier
bwmeta1.element.psjd-fe15d960-d319-4396-b1e1-1a05d0b6d38f
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