HYDROGEL ANTIBACTERIAL COATING FOR SILICONE MEDICAL DEVICES

• Authors: Kamil Kopeć , Michał Żuk , Tomasz Ciach
• Languages of publication: EN

Abstracts

EN

Effective antibacterial coatings are in demand in medicine, especially for urological medical devices such as catheters and stents. We propose the production method of an antibacterial hydrogel coating on polydimethylsiloxane (PDMS, silicone), a popular surface for medical materials. The coating process consists of the following steps: PDMS surface activation (introduction of hydroxyl groups), silanisation (introduction of amine groups) and application of chitosan/alginate hydrogel with the addition of lysozyme as an antibacterial agent using the layer-by-layer method. We investigated the effect of polyion concentration on the coating mass, swelling ratio and stability. We analysed the adsorption of Micrococcus luteus, Escherichia coli and Proteus rettgeri on a PDMS surface using confocal laser scanning microscopy. The chitosan/alginate hydrogel coating with immobilised lysozyme protected the PDMS surface against adhesion for all three tested bacterial strains.

Keywords

EN

alginate; antibacterial coatings; chitosan; layer-by-layer; lysozyme; medical devices

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2021
• Volume: 26
• Pages: 135-147

Contributors

author

Kamil Kopeć

• Faculty of Chemical and Process Engineering, Biomedical Engineering Laboratory, Warsaw University of Technology,

author

Michał Żuk

• Faculty of Chemistry, University of Warsaw

author

Tomasz Ciach

• Faculty of Chemical and Process Engineering, Biomedical Engineering Laboratory, Warsaw University of Technology,

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• Document Type: article