Charakterystyka zwierzęcych modeli doświadczalnych wstrząsu krwotocznego

• Authors: Renata Rybczyk , Agata Żak , Adam Krawiec , Jerzy Jochem

Title variants

EN

Characteristic of experimental animal models of haemorrhagic shock

• Languages of publication: EN

Abstracts

EN

Haemorrhagic shock is a life-threatening status which results from an acute loss of blood and leads to hypotension and hypoperfusion of peripheral tissues. The aim of the present study was to review currently used animal models of haemorrhagic shock. All these models can be classifi ed into two groups – reversible and irreversible. Apart from this classifi cation, haemorrhagic shock models can be divided into controlled (with stabilized initial values of mean arterial pressure, blood gas partial pressure, volume of blood loss) and uncontrolled. Additionally, in the present paper, we characterize one of the most frequently used pressure-controlled, irreversible models of haemorrhagic shock developed by Guarini and al. from University of Modena and Reggio Emilia (Modena, Italy).

PL

Wstrząs krwotoczny jest stanem bezpośredniego zagrożenia życia, wynikającym z nagłej utraty krwi w pełnym składzie, co prowadzi do hipotensji i hipoperfuzji narządowej. Celem obecnej pracy jest przedstawienie stosowanych aktualnie modeli doświadczalnych wstrząsu krwotocznego. Modele te można sklasyfi kować na dwie grupy – modele wstrząsu odwracalnego i nieodwracalnego. Niezależnie od tego podziału wyróżnia się modele wstrząsu kontrolowanego (z mierzonymi wyjściowymi parametrami układu krążenia, takimi jak: średnie ciśnienie tętnicze, prężność gazów oddechowych w krwi tętniczej, objętość traconej krwi) i niekontrolowanego. W pracy scharakteryzowano także jeden z najczęściej stosowanych modeli doświadczalnych wstrząsu krwotocznego, opracowany przez Guariniego i wsp. z University of Modena and Reggio Emilia (Modena, Włochy) model nieodwracalnego wstrząsu krwotocznego z kontrolowaną początkową wartością średniego ciśnienia tętniczego krwi.

Keywords

EN

experimental models; haemorrhagic shock; modele doświadczalne; wstrząs krwotoczny

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2010
• Volume: 64
• Issue: 5-6
• Pages: 69-75

Contributors

author

Renata Rybczyk

• Katedra i Zakład Podstawowych Nauk Medycznych Śląskiego Uniwersytetu Medycznego w Katowicach

author

Agata Żak

• Katedra i Zakład Podstawowych Nauk Medycznych Śląskiego Uniwersytetu Medycznego w Katowicach

author

Adam Krawiec

• Katedra i Zakład Podstawowych Nauk Medycznych Śląskiego Uniwersytetu Medycznego w Katowicach

author

Jerzy Jochem

• Katedra i Zakład Podstawowych Nauk Medycznych Śląski Uniwersytet Medyczny w Katowicach, ul. Piekarska 18, 41-902 Bytom, tel./fax [phone]

References

• 1. Jochem J. Ośrodkowa regulacja krążenia we wstrząsie krwotocznym u szczura – rola układu histaminergicznego. Ann. Acad. Med. Siles. 2004; Suppl. 81, Śląska Akademia Medyczna, Katowice.
• 2. Biewener A., Holch M., Muller U., Veitinger A., Erfurt C., Zwipp H. Eff ect of logistic and medical emergency resources on fatal outcome of severe trauma. Unfallchirurg. 2000; 103: 137–143.
• 3. Alam H.B., Koustova E., Rhee P. Combat casualty care research: from bench to the battlefi eld. World J. Surg. 2005; 29(Suppl 1): S7–S11.
• 4. Carr M.E. Jr. Monitoring of hemostasis in combat trauma patients. Mil. Med. 2004; 169: 11–15.
• 5. Hardway R.M. Wound shock: a history of its study and treatment by military surgeons. Mil. Med. 2004; 169: 265–269.
• 6. Pope A., French G., Longhacker D.E. Fluid resuscitation: state of the science for treating combat casualities and civilian injuries. National Academic Press, New York 1999.
• 7. Vujovic B., Mazlagic D. Epidemiology and surgical management of abdominal war injures in Sarajevo: State Hospital of Sarajevo experience. Prehospital Disaster Med. 1994; 9(Suppl 1): S29–S34.
• 8. Grosso S.M., Keenan J.O. Whole blood transfusion for exsanguinating coagulopathy in a US fi eld surgical hospital in postwar Kosovo. J. Trauma 2000; 49: 145–148.
• 9. Spinella P.C., Perkins J.G., Grathwohl K.W. i wsp. Fresh whole blood transfusion in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital. World J. Surg. 2008; 32: 2–6.
• 10. Borgman M.A., Spinella P.C., Perkins J.G. i wsp. The ratio of blood products transfused aff ects mortality in patients receiving massive transfusions at a combat support hospital. J. Trauma 2007; 63: 805–813.
• 11. Fox C.J., Gillespie D.L., Cox E. i wsp. The eff ectiveness of damage control resuscitation strategy for vascular injury in a combat support hospital: results of a case control study. J. Trauma 2008; 64: S99–S106.
• 12. Alam H.B., Rhee P. New develoments in fl uid resuscitation. Surg. Clin. North Am. 2007; 87: 55–72.
• 13. Barcroft H., McMichael J., Edholm O.G., Sharpey-Schafer E.P. Posthaemorrhagic fainting: Study by cardiac output and forearm fl ow. Lancet 1944; 1: 489–491.
• 14. Evans R.G., Ventura S., Dampney R.A., Ludbrook J. Neural mechanisms in the cardiovascular responses to acute central hypovolaemia. Clin. Exp. Pharmacol. Physiol. 2001; 28: 476–487.
• 15. Guarini S., Bini S., Bazzani C. i wsp. Adrenocorticotropin normalizes the blood levels of nitric oxide in hemorrhageshocked rats. Eur. J. Pharmacol. 1997; 336: 15–21.
• 16. Pereira Y.E., Fagundes J.J., Morandini R.C. i wsp. Hemorrhagic shock infl uence on colonic anastomoses in rats. Evaluation of rupture by liquid distension resistance test. Acta Cir. Bras. 2008; 23: 237–242.
• 17. Jochem J., Żwirska-Korczala K., Rybus- Kalinowska B., Jagodzińska J., Korzonek- Szlacheta I. Infl uence of SKF91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Pol. J. Pharmacol. 2002; 54: 237–244.
• 18. Schneider C.P., Schwacha M.G., Chaudry I.H. Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhage. J. Appl. Physiol. 2007; 102: 113–121.
• 19. Adanir T., Aksun M., Cirit M. i wsp. The renal eff ect of replacement fl uids in controlled severe hemorrhagic shock: an experimental study. Ulus. Travma Acil. Cerrahi. Derg. 2009; 15: 423–432.
• 20. Uji Y., Yamamoto H., Mori T. i wsp. Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation. Surg. Today 2008; 38: 476– 477.
• 21. Sato H., Kasai K., Tanaka T., Kita T., Tanaka N. Role of tumor necrosis factoralpha and interleukin-1beta on lung dysfunction following hemorrhagic shock in rats. Med. Sci. Monit. 2008; 14: BR79- BR87.
• 22. Bruegger D., Kemming G.I., Jacob M. i wsp. Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions. Crit. Care 2007; 11: R130.
• 23. Douzinas E.E., Andrianakis I., Livaditi O. i wsp. The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic infl ammatory response: an experimental study. BMC Physiol. 2008; 8: 15.
• 24. Alam H.B., Hashmi S., Finkelstein R.A. i wsp. Alterations in gene expression after induction of profound hypothermia for the treatment of lethal hemorrhage. J. Trauma 2010; 68: 1084–1098.
• 25. Stern S.A., Dronen S.C., Birrer P., Wang X. Eff ect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann. Emerg. Med. 1993; 22: 155–163.
• 26. Alam H.B., Uy G.B., Miller D. i wsp. Comparative analysis of hemostatic agents in a swine model of lethal groin injury. J. Trauma 2003; 54: 1077–1082.
• 27. Meybohm P., Cavus E., Bein B. i wsp. Cerebral metabolism assessed with microdialysis in uncontrolled hemorrhagic shock after penetrating liver trauma. Anesth. Analg. 2006; 103: 948–954.
• 28. Sailhamer E.A., Chen Z., Ahuja N. i wsp. Profound hypothermic cardiopulmonary bypass facilitates survival without a high complication rate in a swine model of complex vascular, splenic, and colon injuries. J. Am. Coll. Surg. 2007; 204: 642–653.
• 29. Sheng C., Yu Y.H., Zhao K.S., Qin W., Wang C.H. Hypotensive resuscitation combined with polydatin improve microcirculation and survival in a rabbit model of uncontrolled hemorrhagic shock in pregnancy. J. Surg. Res. 2009 [Epub ahead of print].
• 30. Wang Q.C., Xiao N., Diao Y.F., Tian K.L., Fan X.Q., Chen H.S. Mechanism of better result of limited resuscitation in a model of uncontrolled hemorrhagic shock. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004; 16: 473–476.
• 31. Watters J.M., Tieu B.H., Diff erding J.A., Muller P.J., Schreiber M.A. A single bolus of 3% hypertonic saline with 6% dextran provides optimal initial resuscitation after uncontrolled hemorrhagic shock: J. Trauma 2006; 61: 75–81.
• 32. Poloujadoff M.P., Borron S.W., Amathieu R. i wsp. Improved survival after resuscitation with norepinephrine in a murine model of uncontrolled hemorrhagic shock. Anesthesiology 2007; 107: 591–596.
• 33. Mollen K.P., Levy R.M., Hoff man R.A. i wsp. Systemic infl ammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J. Leukoc. Biol. 2008; 83: 80–88.
• 34. Lomas-Niera J.L., Perl M., Chung C.S., Ayala A. Shock and hemorrhage: an overview of animal models. Shock 2005; 1: 33–39.
• 35. Jochem J. Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats. Naunyn Schmiedebergs Arch. Pharmacol. 2004; 369: 418–427.
• 36. Jochem J. Haematological, blood gas and acid-base eff ects of central histamineinduced reversal of critical haemorrhagic hypotension in rats. J. Physiol. Pharmacol. 2001; 52: 447–458.
• 37. Jochem J. Cardiac and regional haemodynamic eff ects of histamine N-methyltransferase inhibitor metoprine in haemorrhage- shocked rats. Infl amm. Res. 2004; 53: 316–323.
• 38. Jochem J. Involvement of arginine vasopressin in endogenous central histamineinduced reversal of critical haemorrhagic hypotension in rats. Infl amm. Res. 2004; 53: 269–276.
• 39. Jochem J. Involvement of the reninangiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. J. Physiol. Pharmacol. 2004; 55: 39–55.
• 40. Jochem J. Involvement of proopiomenalocortin- derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. J. Physiol. Pharmacol. 2004; 55: 57-71.

• Document Type: article