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2010 | 64 | 5-6 | 69-75
Article title

Charakterystyka zwierzęcych modeli doświadczalnych wstrząsu krwotocznego

Title variants
Characteristic of experimental animal models of haemorrhagic shock
Languages of publication
Haemorrhagic shock is a life-threatening status which results from an acute loss of blood and leads to hypotension and hypoperfusion of peripheral tissues. The aim of the present study was to review currently used animal models of haemorrhagic shock. All these models can be classifi ed into two groups – reversible and irreversible. Apart from this classifi cation, haemorrhagic shock models can be divided into controlled (with stabilized initial values of mean arterial pressure, blood gas partial pressure, volume of blood loss) and uncontrolled. Additionally, in the present paper, we characterize one of the most frequently used pressure-controlled, irreversible models of haemorrhagic shock developed by Guarini and al. from University of Modena and Reggio Emilia (Modena, Italy).
Wstrząs krwotoczny jest stanem bezpośredniego zagrożenia życia, wynikającym z nagłej utraty krwi w pełnym składzie, co prowadzi do hipotensji i hipoperfuzji narządowej. Celem obecnej pracy jest przedstawienie stosowanych aktualnie modeli doświadczalnych wstrząsu krwotocznego. Modele te można sklasyfi kować na dwie grupy – modele wstrząsu odwracalnego i nieodwracalnego. Niezależnie od tego podziału wyróżnia się modele wstrząsu kontrolowanego (z mierzonymi wyjściowymi parametrami układu krążenia, takimi jak: średnie ciśnienie tętnicze, prężność gazów oddechowych w krwi tętniczej, objętość traconej krwi) i niekontrolowanego. W pracy scharakteryzowano także jeden z najczęściej stosowanych modeli doświadczalnych wstrząsu krwotocznego, opracowany przez Guariniego i wsp. z University of Modena and Reggio Emilia (Modena, Włochy) model nieodwracalnego wstrząsu krwotocznego z kontrolowaną początkową wartością średniego ciśnienia tętniczego krwi.
Physical description
  • Katedra i Zakład Podstawowych Nauk Medycznych Śląskiego Uniwersytetu Medycznego w Katowicach
  • Katedra i Zakład Podstawowych Nauk Medycznych Śląskiego Uniwersytetu Medycznego w Katowicach
  • Katedra i Zakład Podstawowych Nauk Medycznych Śląskiego Uniwersytetu Medycznego w Katowicach
  • Katedra i Zakład Podstawowych Nauk Medycznych Śląski Uniwersytet Medyczny w Katowicach, ul. Piekarska 18, 41-902 Bytom, tel./fax +48 32 397 65 45
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