The influence of sample preparation and the presence of other active pharmaceutical ingredients (api) and excipients on the use of dsc method in quantification of paracetamol in commercially available tablets

• Authors: Przemysław TALIK , Piotr TALIK , Urszula HUBICKA
• Languages of publication: EN

Abstracts

EN

The direct Differential Scanning Calorimetry method of the determination of paracetamol in commercially available drugs was developed. The method was based on calibration curves obtained from melting enthalpies ΔH of binary mixtures of paracetamol and commonly used excipients such as starch or microcrystalline cellulose in increasing weight ratios. In order to demonstrate how the technological processes of formulating the tablets affects the quantitative studies, the micronized and nonmicronized mixtures were used. The idea of using micronized mixtures was to simulate these technological processes. The appropriate paracetamol contents of the selected pharmaceutical preparations were calculated and compared. The final results demonstrated, that the contents of paracetamol obtained from micronized samples were much closer to those declared by the manufacturer than the nonmicronized. Excluding two drugs, the influence of starch or cellulose on quantification in the micronized group was not observed whereas in the nonmicronized group it was distinctly visible.

Keywords

EN

"DSC"; "Differential Scanning Calorimetry"; "acetaminophen"; "ibuprofen"; "paracetamol"

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: ZOZ Ośrodek UMEA SHINODA-KURACEJO
• Journal: Medicina Internacia Revuo
• Year: 2016
• Volume: 27
• Issue: 107
• Pages: 100-106

Contributors

author

Przemysław TALIK

• Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Krakow, Poland

author

Piotr TALIK

• Medical University of Silesia, School of Medicine in Katowice, Poland

author

Urszula HUBICKA

• Department of Inorganic and Analytical Chemistry, Pharmaceutical Faculty, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Krakow, Poland

References

• 1. Polish Pharmacopoeia, ninth ed. (in accordance with European Pharmacopoeia 7.), Warszawa, 2011.
• 2. Erk N., Ozkan Y., Banoglu E., Ozkan S.A., Senturk Z.: J. Pharm. Biomed. Anal. 24, 469 (2001).
• 3. Raoof J.B., Baghayeri M., Ojani R.: Colloid Surf. B. 95, 121 (2012). 4. Fanjul-Bolado P., Lamas-Ardisana P.J., Hernández-Santos D., Costa-García A.: Anal. Chim. Acta. 638, 133 (2009).
• 5. Felix F.S., Brett C., Angnes L.: J. Pharm. Biomed.
• Anal. 43, 1622 (2007).
• 6. Hopfgartner G., Tonoli D., Varesio E.: Anal. Bioanal. Chem. 402, 2587 (2012).
• 7. Trettin A., Zoerner A.A., Böhmer A., Gutzki F.M., Stichtenoth D.O., Jordan J., Tsikas D.: J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 879, 2274 (2011).
• 8. Vazquez-Roig P., Segarra R., Blasco C., Andreu V., Picó Y.: J. Chromatogr. A. 1217, 2471 (2010).
• 9. Hori Y., Fujisawa M., Shimada K., Hirose Y., Yoshioka T.: Biol. Pharm. Bull. 29, 7 (2006).
• 10. Deconinck E., Sacre P.Y., Baudewyns S., Courselle P., De Beer J.: J. Pharm. Biomed. Anal. 56, 200 (2011).
• 11. Kalogria E., Koupparis M.: J. AOAC Int. 93, 1093 (2010).
• 12. Tonoli D., Varesio E., Hopfgartner G.: J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 904, 42 (2012).
• 13. Tarek B., Tamer A., Randall C.: J. AOAC Int. 92, 1622 (2009).
• 14. An J.H., Lee H.J., Jung B.H.: Biomed. Chromatogr. 26, 1596 (2012).
• 15. Krzek J., Starek M.: J. Planar Chromatogr.—Mod. TLC 12, 356 (1999).
• 16. Campanella L., Magri A., Tomassetti M., Rossi V., Vecchio S.: Drug Dev. Ind. Pharm. 33, 830 (2007). 17. Talik P., Żuromska-Witek B., Hubicka U., Krzek J.; in press Acta Pol. Pharm. 4, 2017.
• 18. Talik P., Czerniecka E., Hubicka U., Krzek J.; in press Acta Pol. Pharm. 4, 2017.
• 19. Boldyrev V.V.: J. Mater. Sci. 39, 5117 (2004).
• 20. Shakhtshneider T.P., Boldyrev V.V.: Mechanochemical synthesis and mechanical activation of drugs, in: E. Boldyreva, V. Boldyrev (eds.), Reactivity of Molecular Solids, Wiley, New York, 1999, vol. 3, p. 271.
• 21. Aigner Z., Berkesi O., Farkas G., Szabo-Revesz P.: J. Pharm. Biomed. Anal. 57, 62 (2012).
• 22. Lin S.Y., Lee C.S.: J. Inclusion Phenom. 7, 477 (1989).
• 23. ICHQ2(R1) Validation of Analytical Procedures: Text and Methodology, 2005.
• 24. Campanella L., Micieli V., Tomassetti M., Vecchio S.: J. Therm. Anal. Calorim 102, 249 (2010).

• Document Type: article