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2019 | 122 | 193-205
Article title

Design, Synthesis, Characterization and Biological evaluation of (4-(7-chloroquinolin-4-yl)piperazin-1-yl)(substitutedphenyl)methanones as antimicrobial agents

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Abstracts
EN
A series of (4-(7-chloroquinolin-4-yl)piperazin-1-yl)(substitutedphenyl)methanones were prepared via multistep synthesis which involved acrylation without base, cyclisation, hydrolysis, decarboxylation, electrophilic chlorination reactions and subsequent chloro-amine coupling with various substituted benzoyl chloride derivatives. The structure of the synthesized compounds was established by using elemental analysis, FT-IR, 1H NMR, 13C NMR and Mass spectroscopy. All the novel compounds have been tested on thin layer chromatographic plate for purity and evaluated for their antimicrobial activity against gram positive and gram negative bacteria which demonstrated moderate to good antimicrobial activity.
Year
Volume
122
Pages
193-205
Physical description
Contributors
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
author
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot – 360005, Gujarat, India
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-f317208b-2973-466b-8883-2d6835b796fe
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