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2017 | 71 | 193-203
Article title

Analysis of relationship between UMOD polymorphisms rs13335818, rs4293393 and rs13333226 and risk of chronic kidney disease caused by chronic glomerulonephritis

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Analiza związku polimorfizmów rs13335818, rs4293393 i rs13333226 genu UMOD z występowaniem przewlekłej choroby nerek na tle przewlekłego kłębuszkowego zapalenia nerek
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EN
INTRODUCTION: Chronic glomerulonephritis is one of the common causes of chronic kidney disease that can lead to end-stage renal failure and the need for renal replacement therapy. Understanding the aetiology of this disease and its risk factors can help develop new methods of early diagnosis and effective therapy. Uromodulin is a protein with a broad spectrum of activity, and is involved in the key pathways that regulate kidney homeostasis. AIM OF THE STUDY: The aim of the study was to analyse the relationship between three selected polymorphisms (rs13335818, rs4293393 and rs13333226) of the uromodulin gene (UMOD) and the risk of chronic kidney disease caused by chronic glomerulonephritis. MATERIAL AND METHODS: 113 patients with chronic glomerulonephritis and eGFR < 60 ml/min/1.73 m2 (experimental group) and 196 patients from the General Outpatient Clinic without a history of renal disease and eGFR > 60 ml/min/1.73 m2 (control group) were recruited for the study. The study protocol assumed a one-time blood collection for genetic testing and serum creatinine level determination. Genetic material was isolated from the peripheral blood lymphocytes of the subjects. Genotyping of the analysed polymorphisms was performed using TaqMan SNP Genotyping Assay kits. The results were processed with statistical methods using Statistica 10 and Microsoft Office Exel 2003 software, the Mann-Whitney U test and the χ2 test. Statistical significance was adopted at p < 0.05. RESULTS: No statistically significant differences in the distribution of genotypes between the experimental and control groups were found for any of the three analysed UMOD variants. CONCLUSIONS: UMOD polymorphisms rs13335818, rs4293393 and rs13333226 are not associated with the risk of chronic kidney disease caused by chronic glomerulonephritis.
PL
WSTĘP: Przewlekłe kłębuszkowe zapalenie nerek jest jedną z częstych przyczyn przewlekłej choroby nerek mogącej prowadzić do ich schyłkowej niewydolności i konieczności stosowania terapii nerkozastępczej. Poznanie etiologii tej choroby oraz czynników ryzyka daje nadzieję na wdrożenie nowych metod wczesnej diagnostyki i skutecznej terapii. Uromodulina jest białkiem prezentującym szerokie spektrum działań, włączonym w kluczowe szlaki warunkujące homeostazę nerek. CEL PRACY: Celem pracy była ocena związku wybranych trzech polimorfizmów (rs13335818, rs4293393 i rs13333226) genu uromoduliny (UMOD) z występowaniem przewlekłej choroby nerek na tle przewlekłego kłębuszkowego zapalenia nerek. MATERIAŁ I METODY: Do badania zrekrutowano 113 chorych z przewlekłym kłębuszkowym zapaleniem nerek i eGFR < 60 ml/min/1,73 m2 (grupa badana) oraz 196 pacjentów Poradni Ogólnej POZ bez chorób układu moczowego w wywiadzie, z eGFR > 60 ml/min/1,73 m2 (grupa kontrolna). Protokół badania przewidywał jednorazowe pobranie krwi do wykonania badań genetycznych oraz w celu oznaczenia stężenia kreatyniny w surowicy. Materiał genetyczny wyizolowano z limfocytów krwi obwodowej badanych. Genotypowanie badanych polimorfizmów przeprowadzono z wykorzystaniem zestawów TaqMan SNP Genotyping Assay. Uzyskane wyniki opracowano statystycznie na podstawie programów Statistica 10 i Microsoft Office Exel 2003 z wykorzystaniem: testu Manna-Whitneya i testu χ2. Za granice istotności statystycznej przyjęto wartości p < 0,05. WYNIKI: W zakresie żadnego z trzech badanych polimorfizmów UMOD nie stwierdzono znamiennych statystycznie różnic w rozkładzie genotypów pomiędzy grupami badaną a kontrolną. WNIOSKI: Nie wykazano związku polimorfizmów rs13335818, rs4293393 i rs13333226 genu UMOD z występowaniem przewlekłej choroby nerek na tle przewlekłego kłębuszkowego zapalenia nerek.
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Year
Volume
71
Pages
193-203
Physical description
Contributors
  • Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
  • Katedra Nefrologii, Transplantologii i Chorób Wewnętrznych, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach
author
  • Niepubliczny Zakład Opieki Zdrowotnej Rodzinna Służba Zdrowia "Gmin-Med" Sp. z o.o. w Dobieszowicach
  • Katedra Nefrologii Pediatrycznej, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
  • Katedra Nefrologii, Transplantologii i Chorób Wewnętrznych, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach
  • Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
  • Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
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bwmeta1.element.psjd-f0eb5037-5db5-4627-a9d0-6edd7eb06f40
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