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2014 | 19 | 103-110
Article title

USE POLYVINYLPYRROLIDONE IN TECHNOLOGY OF GYNAECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

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Abstracts
EN
metric ratio of 1:1, 2:1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the pH from 4.28 to 4.52 for 1:1 and from 2.58 to 3.30 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the dynamic viscosity from 84 to 510 mPa.s for 1:1 gels and from 47 to 386 mPa.s for the 8:1 ratio. The gels obtained from powders possess the work of adhesion - the energy needed to separate the gel from the probe was 15.2 g/s for gels with 5% polyvinylpyrrolidone K-15, 52.76 g/s for gels with 5% polyvinylpyrrolidone K-30, and 56.6 g/s for gels containing 5% polyvinylpyrrolidone K-90. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Year
Volume
19
Pages
103-110
Physical description
Contributors
  • Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy The “Silesian Piasts” Memorial Medical University of Wroclaw,
References
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  • 4. Kubis AA, Małolepsza-Jarmołowska K; (1996) Studies on gynaecological hydrophiling preparations comprising lactic acid. Part 1: Effects of lactic acid and hydrophiling agents on physical and chemical properties of methylcellulose gels. Pharmazie 51, 989 – 990.
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  • 7. Małolepsza-Jarmołowska K, Kubis AA; (2001) Studies on gynaecological hydrophilic lactic acid preparations. Part 4: Effects of polyvinyl pyrrolidone K-90 on properties of methylcellulose gels. Pharmazie 56, 160 – 162.
  • 8. Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 260 – 262.
  • 9. Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 6: Use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 334 – 336.
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-f0c23a44-24b7-43f6-ba1c-4e8228eaab4a
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