G6PD Activity in Malaria Infected Children in Owerri
Languages of publication
G6PD activity in malaria infected children in Owerri was studied. Blood samples were collected from fifty one (51) children hospitalized in Federal Medical Center (FMC) and analyzed using standard Medical Laboratory methods. Results revealed that out of the 51 children examined; 26 were male and 25 were females. 39 representing 76.47% of the total malaria infected children numbers were G6PD deficient while 12 representing 23.53% had their G6PD normal. Two different plasmodium species and their percentage occurrences were observed as follows; Plasmodium falciparum (78.43%) and Plasmodium malariae (21.57%). Result further showed that male children were more (P < 0.05) deficient than females with percentage levels of 61.53% and 38.47% respectively. Children between the ages of 49-60 months was observed to be more (P < 0.05) G6PD deficient with percentage 25.64%, while those between 0-12 months were least G6PD deficient with percentage of 8.3% (P < 0.05). There is therefore urgent need for public enlightenment on public health implications, need for proper hygiene as well as strategies for preventing and controlling mosquito bites which as a result curses malaria which has a high risk of degenerating Glucose-6-phosphate dehydrogenase (G6PD) deficiency in children.
-  Reclos, G., Hatzidakis, C. and Schulpis, K. (2000). Glucose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening. Journal of Medical Screening 7(1), 46-51
-  Noori-Daloii, M., Najafi, L., Ganji, S., Hajebrahimi, Z. and Sanati, M. (2004). Molecular identification of mutations in G6PD gene in patients with favism in Iran. Journal of physiology and biochemistry 60(4), 273-277
-  Frank, J. (2005): Diagnosis and management of G6PD deficiency. Journal American family physician 72(7), 1277
-  Beutler, E. (1993). The study of glucose-6-phosphate dehydrogenase. History and molecular biology 33(6), 78-81
-  Glader, B. and Lukens, J. (1999). Glucose-6-phosphate dehydrogenase deficiency and related disorders of hexose monophosphate shunt and glutathione metabolism. Wintrobe’s Clinical hematology, 1, 1176-1190
-  Ruwende C & Hill A (1998) Glucose-6-phosphate dehydrogenase deficiency and malaria. J. Mol. Med. (Berl) 76( 8):581-588.
-  Moskaug, J., Carlsen, H., Myhrstad, M. and Blomhoff, R. (2004). Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mechanisms of ageing and development 125(4), 315-324
-  Cheesbrough, M. (2006). District laboratory practice in tropical countries, 2nd Ed. Update part 1, Pp. 256, 350-352
-  Ninokata, A., Kimura. R., Samakkarn, U., Settheetham-Ishida, W. and Ishida, T. (2006): Coexistence of five G6PD variants indicates ethnic complexity of Phuket islanders, Southern Thailand. J. Hum. Genet. 51(5):424-428.
-  White, N. (2008). The role of anti-malarial drugs in eliminating malaria. Malar J 7(1), S8
-  Hoyer, S., Nguon, S., Kim, S., Habib, N., Khim, N., Sum, S., Christophel, E., Bjorge, S., Thomson, A., Kheng, S., Chea, N., Yok, S., Top, S., Ros, S., Sophal, U., Thompson, M., Mellor, S., Ariey, F., Witkowski, B., Yeang, C., Yeung, S, Duong S, Newman RD, Ménard D: Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. PLoS One 7(45), 797
-  Mason, P., Stevens, D., Luzzatto, L., Brenner, S. and Aparicio, S. (1995). Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD). Genomics 26(3), 587-591
-  Koehler, A. and Van-Noorden, C. (2003). Reduced nicotinamide adenine dinucleotide phosphate and the higher incidence of pollution-induced liver cancer in female flounder. American Journal of Physical Anthropology 23(34), 67-89
-  Opeyemi R. Salau, Taofeek Ewumi, Bunmi E. Owolabi, Gabriel O. Ajayi, Oluwaseun E. Ajayi. Regional Distribution of Malaria in Ekiti State, Nigeria. World Scientific News 55 (2016) 89-100
Publication order reference