CHARACTERIZATION OF MIXED LANGMUIR MONOLAYERS OF CYCLOSPORINE A WITH THE PHOSPHOLIPID DPPC AT THE CHITOSAN SUBPHASE

• Authors: Klaudia Woźniak , Małgorzata Jurak , Agnieszka Ewa Wiącek
• Languages of publication: EN

Abstracts

EN

The properties of one-component and mixed monolayers of phospholipid 1,2–dipalmitoyl–sn–glycero–3–phosphocholine (DPPC) and polypeptide cyclosporine A (CsA) on the chitosan subphase were studied. DPPC is the main component that builds biological membranes, and CsA is an immunosuppressive drug typically used in medicine to prevent transplant rejections. The stability and reversibility of compression of these insoluble monolayers in the presence of chitosan (Ch) were examined by the Langmuir technique. The stability of the monolayers depended on the monolayer composition as well as the initial pressure (π0) of the relaxation process. The smallest changes in the relative pressure as a function of time were obtained at π0 = 10 mN/m. During compression–decompression cycles, the effect of chitosan was noticeable and caused isotherm shifts.

Keywords

EN

Langmuir monolayer; chitosan; cyclosporine A; monolayer stability

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2020
• Volume: 25
• Pages: 227 - 235

Contributors

author

Klaudia Woźniak

• Department of Interfacial Phenomena, Institute of Chemical Science, Faculty of Chemistry, Maria Curie–Skłodowska University

author

Małgorzata Jurak

• Department of Interfacial Phenomena, Institute of Chemical Science, Faculty of Chemistry, Maria Curie–Skłodowska University

author

Agnieszka Ewa Wiącek

• Department of Interfacial Phenomena, Institute of Chemical Science, Faculty of Chemistry, Maria Curie–Skłodowska University

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• Document Type: article