Pituitary adenoma occurring with acromegaly coexisting with partially empty sella syndrome
Languages of publication
Pituitary microadenoma occurring with acromegaly coexisting with empty sella syndrome is a rare clinical case. The main symptoms result from the presence of hormonally active pituitary tumor. Empty sella syndrome may hinder correct and prompt diagnosis, which may be important for effective therapy. We present a case of a 67-year-old woman admitted to hospital with acromegaly. MRI of the pituitary revealed partially empty sella and pituitary microadenoma. The patient underwent surgery. Follow-up MRI revealed regression of the pituitary adenoma without signs of recurrence during observation. We also present a review of literature.
- 1. Jadresic A, Banks LM, Child DF et al. The acromegaly syndrome. Relation between clinical features, growth hormone values and radiological characteristics of the pituitary tumours. Q J Med 1982; 51: 189-204.
- 2. Bjerre P, Lindholm J, Videbaek H. The spontaneous course of pituitary adenomas and occurrence of an empty sella in untreated acromegaly. Clin Endocrinol Metab 1986; 63: 287-291.
- 3. Liu W, Zhou H, Neidert MC et al. Growth hormone secreting pituitary microadenomas and empty sella – an under-recognized association? Clin Neurol Neurosurg 2014; 126: 18-23.
- 4. Gondim A, Schops M, Ferreira E et al. Acromegaly due to an ectopic pituitary adenoma in the sphenoid sinus. Acta Radiol 2004; 45: 689-691.
- 5. Hori E, Akai T, Kurimoto M et al. Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. Clin Neurosci 2002; 9: 196-199.
- 6. Coulson C, Sidcliq MA, Johnson AP. Empty sella syndrome associated with a hyperfunctioning microadenoma invading the clivus. Neurosurg 2007; 21: 623-625.
- 7. Appel G, Bergsneider M, Vinters H et al. Acromegaly due to an ectopic pituitary adenoma in the clivus case report and review of literature. Pituitary 2012; 15(suppl. 1): S53-56.
- 8. Osella G, Orlandi F, Caraci P et al. Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella. J Endocrinol Invest 2003; 26: 163-169.
- 9. Mnif Feki M, Mnif F, Charfi N et al. Ectopic secretion of GHRH by a pancreatic neuroendocrine tumor associated with an empty sella. Ann Endocrinol (Paris) 2011; 72: 522-525.
Publication order reference