Synthesis, spectral studies and antimicrobial activity of thiosemicarboximide derivatives containing pyridine nucleus

• Authors: Heena Patel , Neha Bhoraniya , Priyanka Pankhaniya , Dipak M. Purohit
• Languages of publication: EN

Abstracts

EN

The Thiosemicarboximide derivatives of (5a-5j) were synthesized by the condensation of Chalcone derivatives (4a-4j) with H2N-NH-CS-NH2 in the presence of glacial acetic acid. The structures of newly synthesized compounds were confirmed based on 1H-NMR, mass spectra, and IR data. All the newly synthesized compounds were screened for their antibacterial activity against Gram +ve Bacteria Bacillus subtilis, Staphylococcus aureus, and Gram –ve Bacteria Escherichia coli, Pseudomonas aeruginosa and Fungi Aspergillus niger.

Keywords

EN

Anti-microbial activity; Pyridine; Thiosemicarboximide derivatives

Discipline

• BIOCHEMISTRY: BIOCHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2024
• Volume: 54
• Pages: 9-16

Contributors

author

Heena Patel

• Department of Chemistry, Shree M & N Virani Science College, Kalawad Road, Rajkot - 360005, Gujarat, India

author

Neha Bhoraniya

• Department of Chemistry, Shree M & N Virani Science College, Kalawad Road, Rajkot - 360005, Gujarat, India

author

Priyanka Pankhaniya

• Department of Chemistry, Shree M & N Virani Science College, Kalawad Road, Rajkot - 360005, Gujarat, India

author

Dipak M. Purohit

• Department of Chemistry, Shree M & N Virani Science College, Kalawad Road, Rajkot - 360005, Gujarat, India

References

• [1] Allaka, T. R.; Katari, N. K. Synthesis of Pyridine Derivatives for Diverse Biological Activity Profiles: A Review. Recent Developments in the Synthesis and Applications of Pyridines 2023, 605–625.
• [2] Prachayasittikul, S.; Pingaew, R.; Worachartcheewan, A.; Sinthupoom, N.; Prachayasittikul, V.; Ruchirawat, S.; Prachayasittikul, V. Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents. Mini Reviews in Medicinal Chemistry 2017, 17 (10), 869–901.
• [3] Krause, M.; Foks, H.; Gobis, K. Pharmacological Potential and Synthetic Approaches of Imidazo [4, 5-b] Pyridine and Imidazo [4, 5-c] Pyridine Derivatives. Molecules 2017, 22 (3), 399
• [4] Narendar, P.; Parthiban, J.; Anbalagan, N.; Gunasekaran, V.; Leonard, J. T. Pharmacological Evaluation of Some New 2-Substituted Pyridine Derivatives. Biological and Pharmaceutical Bulletin 2003, 26 (2), 182–187.
• [5] Kumar, S.; Sharma, P. K.; Dudhe, R.; Kumar, N. Pyridine: Potential for Biological Activities. Journal of Chronotherapy and Drug Delivery 2011, 2 (2), 71–78.
• [6] Kosobokov, M.; Cui, B.; Balia, A.; Matsuzaki, K.; Tokunaga, E.; Saito, N.; Shibata, N. Importance of a Fluorine Substituent for the Preparation of Meta‐and para‐Pentafluoro‐λ6‐sulfanyl‐Substituted Pyridines. Angewandte Chemie International Edition 2016, 55 (36), 10781–10785.
• [7] Shabir, G.; Saeed, A.; Zahid, W.; Naseer, F.; Riaz, Z.; Khalil, N.; Muneeba; Albericio, F. Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016–2022). Pharmaceuticals 2023, 16 (8), 1162.
• [8] Aly, A. A.; Hassan, A. A.; Abd El‐latief, E. S. An Update of the Use of Thiocarbohydrazides and Thiosemicarbazides in the Preparation of Heterocycles and Their Biological Importance. Journal of Heterocyclic Chemistry 2018, 55 (10), 2196–2223.
• [9] El-Gammal, O.; Mostafa, M. Synthesis, Characterization, Molecular Modeling and Antioxidant Activity of Girard′ s T Thiosemicarbazide and Its Complexes with Some Transition Metal Ions. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014, 127, 530–542.
• [10] Dincel, E. D.; Guzeldemirci, N. U. Synthesis and Computer-Aided Drug Design Studies of Novel Thiosemicarbazide Derivatives as Potent and Target-Oriented Anti-Cancer Agents. Medicine 2020, 9 (2), 305–313.
• [11] Başoğlu‐Ünal, F.; Becer, E.; Ensarioğlu, H. K.; Güzeldemirci, N. U.; Kuran, E. D.; Vatansever, H. S. A Newly Synthesized Thiosemicarbazide Derivative Trigger Apoptosis Rather than Necroptosis on HEPG2 Cell Line. Chemical Biology & Drug Design 2024, 103 (1), e14355.
• [12] Patel, H.; Bhoraniya, N.; Pankhaniya, P.; Dave, D.; Purohit, D. M. Synthesis and antimicrobal screening of new chalcones, isoxazoles molecules bearing pyridine nucleus. World Journal of Pharmaceutical Research, Volume 13, Issue 3, 899-908, 2024.
• [13] Arora, S.; Agarwal, S.; Singhal, S. Anticancer Activities of Thiosemicarbazides/Thiosemicarbazones: A Review. Int J Pharm Pharm Sci, Vol 6, Issue 9, 34-41, 2014.
• [14] Yousef, T. A.; Badria, F. A.; Ghazy, S. E.; El-Gammal, O. A.; El-Reash, G. M. A. In Vitro and in Vivo Antitumor Activity of Some Synthesized 4-(2-Pyridyl)-3-Thiosemicarbazides Derivatives. International Journal of Medicine and Medical Sciences 2011, 3 (2), 37–46.
• [15] Jain, J.; Kumar, Y.; Stables, J.; Sinha, R. Menthone Semicarbazides and Thiosemicarbazides as Anticonvulsant Agents. Medicinal Chemistry 2010, 6 (1), 44–50.
• [16] Plech, T.; Wujec, M.; Siwek, A.; Kosikowska, U.; Malm, A. Synthesis and Antimicrobial Activity of Thiosemicarbazides, s-Triazoles and Their Mannich Bases Bearing 3-Chlorophenyl Moiety. European Journal of Medicinal Chemistry 2011, 46 (1), 241–248.
• [17] Dziduch, K.; Kołodziej, P.; Paneth, A.; Bogucka-Kocka, A.; Wujec, M. Synthesis and Anthelmintic Activity of New Thiosemicarbazide Derivatives—A Preliminary Study. Molecules 2020, 25 (12), 2770.
• [18] Siwek, A.; Stefańska, J.; Dzitko, K.; Ruszczak, A. Antifungal Effect of 4-Arylthiosemicarbazides against Candida Species. Search for Molecular Basis of Antifungal Activity of Thiosemicarbazide Derivatives. Journal of Molecular Modeling 2012, 18, 4159–4170.
• [19] Blower, P. J. 30 Inorganic Pharmaceuticals. Annual Reports Section "A". Inorganic Chemistry 2004, 100, 633–658.
• [20] Barry, A.; Lasner, R. Inhibition of Bacterial Growth by the Nitrofurantoin Solvent Dimethylformamide. Antimicrobial agents and chemotherapy 1976, 9 (3), 549–550.

• Document Type: article