PROTEIN DELIVERY BY NANOPARTICLES FORMED BY CHITOSAN-N-ACYL DERIVATIVES

• Authors: Anastasia А. Zubareva , Alla.V. Ilyina , Аlexandr N. Levov , Vera S. Zueva , Еlena V. Svirshchevskaya , Valery P. Varlamov
• Languages of publication: EN

Abstracts

EN

Biodegradable nanoparticulated carriers have important potential applications for administration of therapeutic proteins and peptides. Chitosan based nanoparticles have attracted attention due to their biological properties such as biodegrability and biocompatibility. However, chitosan nanoparticles are not stable in colloid form. Therefore, to increase the stability of these particles is an important problem. The aim of this work was to obtain stable nanoparticles formed by N-acyl derivatives of chitosan by ionic gelation and to investigate their ability to interact with acidic, neutral and basic proteins.

Keywords

EN

N-acyl derivatives of chitosan; chitosan nanoparticles; ionic gelation; protein delivery

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2011
• Volume: 16
• Pages: 61 - 70

Contributors

author

Anastasia А. Zubareva

• Centre «Bioengineering» RAS

author

Alla.V. Ilyina

• Centre «Bioengineering» RAS

author

Аlexandr N. Levov

• Centre «Bioengineering» RAS

author

Vera S. Zueva

• Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of RAS

author

Еlena V. Svirshchevskaya

• Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of RAS

author

Valery P. Varlamov

• Centre «Bioengineering» RAS

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• Document Type: article