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2016 | 14 | 3 | 174–177
Article title

Incidentally diagnosed epithelioid trophoblastic tumor immediately after delivery: a case report

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Title variants
PL
Przypadkowe rozpoznanie nowotworu nabłonkowatokomórkowego trofoblastu bezpośrednio po porodzie – opis przypadku
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EN PL
Abstracts
EN
Epithelioid trophoblastic tumor is a rare malignant lesion of gestational trophoblastic disease, and constitutes an abnormal proliferation of placental trophoblasts. Patients with epithelioid trophoblastic tumor are usually of reproductive age, and have had previous gestations including full-term deliveries, molar pregnancies and abortions. The interval between antecedent gestational events and the diagnosis of epithelioid trophoblastic tumor usually ranges from 0 to 264 months (mean, 84 months). Herein, we report a 42-year-old Korean woman (gravida 2, para 2). At 38 weeks of gestation, she underwent a repeat cesarean section and then hysterectomy due to uterine atony. She was incidentally diagnosed with epithelioid trophoblastic tumor, and postoperatively no metastatic disease was observed. The patient presented no clinical evidence of tumor recurrence for 5 years after surgery. This case is remarkable because epithelioid trophoblastic tumor is a rare disease, and the diagnosis of epithelioid trophoblastic tumor followed immediately after delivery.
PL
Nowotwór nabłonkowatokomórkowy trofoblastu (epithelioid trophoblastic tumor) to rzadka złośliwa postać ciążowej choroby trofoblastycznej. Charakteryzuje się nieprawidłowym rozrostem komórek trofoblastu. Zmiany tego typu rozpoznaje się u kobiet w wieku rozrodczym z ciążą w wywiadzie, zarówno donoszoną, jak i przedwcześnie zakończoną, również z zaśniadem groniastym. Czas między ciążą a rozpoznaniem nowotworu nabłonkowatokomórkowego trofoblastu wynosi od 0 do 264 miesięcy (średnio 84 miesiące). Przedstawiamy przypadek 42-letniej pacjentki z Korei (gravida 2, para 2), u której w 38. tygodniu ciąży wykonano cięcie cesarskie, a następnie histerektomię ze względu na atonię macicy. Przypadkowo rozpoznano nowotwór nabłonkowatokomórkowy trofoblastu, a po zabiegu nie zaobserwowano przerzutów. Pacjentka nie wykazywała cech nawrotu przez 5 lat po zabiegu. Prezentowany przypadek jest szczególny, ponieważ nowotwór nabłonkowatokomórkowy trofoblastu to rzadkość, a rozpoznano go bezpośrednio po porodzie.
Discipline
Publisher

Year
Volume
14
Issue
3
Pages
174–177
Physical description
Contributors
  • Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, 26, Daesingongwon-ro, Seo-gu, Busan, 49201, Republic of Korea
author
  • Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, 26, Daesingongwon-ro, Seo-gu, Busan, 49201, Republic of Korea, mdpjw1216@gmail.com
References
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  • 2. Meydanli MM, Kucukali T, Usubutun A et al.: Epithelioid trophoblastic tumor of the endocervix: a case report. Gynecol Oncol 2002; 87: 219–224.
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  • 4. Oldt RJ 3rd, Kurman RJ, Shih IeM: Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin. Am J Pathol 2002; 161: 1033–1037.
  • 5. Shen X, Xiang Y, Guo L et al.: Analysis of clinicopathologic prognostic factors in 9 patients with epithelioid trophoblastic tumor. Int J Gynecol Cancer 2011; 21: 1124–1130.
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  • 7. Shih IM, Kurman RJ: Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. Hum Pathol 1998; 29: 27–33.
  • 8. Shih IM, Kurman RJ: Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol 1998; 22: 1393–1403.
  • 9. Shih IM, Seidman JD, Kurman RJ: Placental site nodule and characterization of distinctive types of intermediate trophoblast. Hum Pathol 1999; 30: 687–694.
  • 10. Sung WJ, Shin HC, Kim MK et al.: Epithelioid trophoblastic tumor: clinicopathologic and immunohistochemical analysis of three cases. Korean J Pathol 2013; 47: 67–73.
  • 11. Vencken PM, Ewing PC, Zweemer RP: Epithelioid trophoblastic tumour: a case report and review of the literature. J Clin Pathol 2006; 59: 1307–1308.
  • 12. Zhang X, Zhou C, Yu M et al.: Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. Int J Clin Exp Pathol 2015; 8: 7254–7259.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-eac56c80-93e0-4480-b772-e295ce03daa3
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