Udział zaburzeń szlaku FGF/FGFR w transformacji nowotworowej piersi, jajnika oraz błony śluzowej trzonu macicy

• Authors: Agnieszka Szymczyk , Ewa Forma

Title variants

EN

The role of FGF/FGFR signaling pathway disorders in breast, ovarian and endometrial cancerogenesis

• Languages of publication: PL

Abstracts

PL

Czynniki wzrostu fibroblastów (FGF) oraz ich receptory (FGFR) stanowią liczną rodzinę białek zaangażowanych w regulację wielu procesów kluczowych dla prawidłowego funkcjonowania komórek. Na przestrzeni ostatnich lat wykazano, że zaburzenia szlaku FGF/FGFR odgrywać mogą istotną rolę w transformacji nowotworowej wielu narządów, w tym piersi, jajnika i endometrium. Nieprawidłowa ekspresja genów kodujących FGF i ich receptory, a także ich mutacje skutkować mogą m.in. zaburzeniami procesów wzrostu i apoptozy. Zaburzenia sygnalizacji szlaku FGF/FGFR mogą również leżeć u podstaw nabywania przez komórki nowotworowe oporności na terapię hormonalną.

EN

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are the members of a large protein family involved in the regulation of many cellular processes which are essential for proper functioning of cells. It was found that the disregulation of FGF/FGFR signaling pathway can lead to the cancerogenesis of many tissues including the breast, the ovary and the endometrium. The alteration in FGF and FGFR gene expression and their mutation may induce growth and survival signals and suppress apoptosis. The Disregulation of FGF/FGFR signaling pathway can also promote endocrine therapy resistance.

Keywords

EN

FGF; FGFR; breast cancer; endometrial cancer; ovarian cancer; rak endometrium; rak jajnika; rak piersi

Discipline

• MEDICINE: MEDICINE

• Publisher: Łódzkie Towarzystwo Naukowe
• Journal: Folia Medica Lodziensia
• Year: 2014
• Volume: 41
• Issue: 1
• Pages: 93-105

Contributors

author

Agnieszka Szymczyk

• Katedra Cytobiochemii, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki

author

Ewa Forma

• Katedra Cytobiochemii, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki

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