Preferences help
enabled [disable] Abstract
Number of results
2010 | 15 | 55 - 62
Article title

Chitosan dichloro acetic acid salts

Title variants
Languages of publication
The salts of dichloroacetic acid were obtained from chitosans of different deacetylation degrees (69÷97%) and viscosity-average molecular weights (61÷327 kDa). The mole ratio of dichloroacetic acid to amine groups was 1. The chemical and physical properties of the salts were evaluated by determining the dry weight, the content of ash, acid, insoluble substances, kinematic viscosity, and pH. The studied salts had a low contents of water (<10%), inorganic pollutants (<0.2%), and a low insoluble substances fraction (<0.15%). The determined acid content was similar to the theoretical content. The physical properties of the chitosan influenced the kinematic viscosity of the salt solutions. The kinematic viscosity decreased when the viscosity-average molecular weights of the chitosan decreased. The properties of chitosan did not significantly impact the pH of the salt solutions. This depended on the pKa of the acid. The chemical and physical properties of the salts can be altered by neutralizing the dichloroacetate solutions to a pH at which no distinct change in clarity occurs.

55 - 62
Physical description
  • Bonnet S., Archer S. L., Allalunis-Turner J., Haromy A., Beaulieu Ch., Thompson R., Lee Ch. T., Lopaschuk G. D., Puttagunta L., Bonnet S., Harry G., Hashimoto K., Porter Ch. J., Andrade M. A., Thebaud B., Michelakis E. D.; (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11, pp. 37-51.
  • Lekka M., Laidler P., Ignacak J., Łabędź M., Lekki J., Struszczyk H., Stachura Z., Hrynkiewicz A. Z.; (2001) The effect of chitosan on stiffness and glycolytic activity of human bladder cells. Biochimica et Biophysica Acta 1540, pp. 127-136.
  • Ignacak J., Pałka I., Struszczyk H.; (2004) The effect of microcrystalline chitosan on the in vitro proliferation of Ehrlich ascites tumor (EAT) cells and normal mouse epithelium. In: Struszczyk H. (ed), Progress on chemistry of chitin and its derivatives, Vol. 10, Polish Chitin Society, Łódź, 113-119.
  • Ignacak J., Dulińska-Litewka J., Pałka I., Struszczyk H.; (2006) The effect of highly deacetylated microcrystalline chitosan on the pyruvate kinase gene expression in normal mouse mammary epithelial cells and Ehrlich ascites tumor (EAT) cells. In: Jaworska M (ed), Progress on chemistry of chitin and its derivatives, Vol. 11, Polish Chitin Society, Łódź, pp. 137-143.
  • Prashanth K. V. H., Tharanathan R. N.; (2005) Depolymerized products of chitosan as potent inhibitors of tumor-induced angiogenesis. Biochimica et Biophysica Acta 1722, pp. 22– 29.
  • Je J. Y., Cho Y., Kim S. K.; (2006) Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation. Bioorg Med Chem Letters 16, pp. 2122–2126
  • Austin P. R.; (1986) Dry free-flowing water-soluble complexes of chitosan. U. S. Patent 4,574,150.
  • Austin P. R., Sennett S.; (1986) Dry chitosan salts and complexes of aliphatic carboxylic acids. In: Muzzarelli R, Jeuniaux Ch, Gooday GW (eds), Chitin in nature and technology, Plenum Press, New York and London, pp. 279-286.
  • Wojtasz-Pająk A.; (2008) Chitosan dicarboxylic acid salts. In: Jaworska M (ed), Progress on chemistry of chitin and its derivatives, Vol. 13, Polish Chitin Society, Łódź, pp. 25-33.
  • Wojtasz-Pająk A.; (2000) Influence of parameters of raw material on properties of products of chitin homogeneous deacetylation. In: Struszyk H (ed), Progress on chemistry of chitin and its derivatives, Vol. 6, Polish Chitin Society, Łódź, pp. 7-14.
  • Pettersen H., Sannes A., Holme H. K., Kristensen Å., Dornish M., Smidsrød O.; (2000) Thermal depolymerization of chitosan salts. In: Peter MG, Domard A, Muzzarelli RAA (eds), Advances in chitin science Vol. 4, Universität Potsdam, Potsdam, pp. 422-428.
  • De Britto D., Campana-Filho Paulo S. P.; (2007) Kinetics of thermal degradation of chitosan. Thermochimica acta 465, pp. 73-82.
  • Hamdine M. M., Heuzey C., Bégin A.; (2005) Effect of organic and inorganic acids on concentrated chitosan solutions and gels. Int J Biol Macromol 37, pp. 134-142.
  • Wojtasz-Pająk A., Ulański P.; (2003) Preliminary studies on the polydispersity of chitosan obtained under heterogeneous condition. In: Struszczyk H (ed), Progress on chemistry of chitin and its derivatives, Vol. 9 , Polish Chitin Society, Łódź, pp. 29-40.
  • Vårum K. J., Ottøy M. H., Smidsrød O.; (1994) Water-solubility of partially N-acetylated chitosans as a function of pH: effect of chemical composition and depolymerisation. Carbohydr Polym 25, pp. 65-70.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.