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2016 | 70 | 281–285
Article title

Wpływ niedokrwistości na stan neurologiczny oraz funkcjonalny chorych w ostrej fazie niedokrwiennego udaru mózgu – raport wstępny

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EN
The impact of anemia on neurological and functional state in patients in acute stroke – preliminary report
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Abstracts
EN
INTRODUCTION: Anemia is a risk factor for cerebrovascular events. The aim of this study was to evaluate the prevalence of anemia among patients who underwent a first-ever stroke and its impact on the neurological and functional state in the acute phase of stroke. MATERIAL AND METHODS: The prospective study encompassed 109 patients (53 women) aged 72.8 ± 11.12 after stroke. We analyzed their neurological state on the first day after stroke by NIHSS and their functional status on the 14th day after the onset of stroke by the modified Rankin scale among patients with anemia and without anemia. RESULTS: Anemia was found in 34 patients, in 15 women and 19 men; 8 patients aged ≤ 65 years. The neurological deficit according to NIHSS, functional status at the level of 3–5 by mRS and death did not differ significantly between the analyzed groups. An independent predictor of a worse functional status on the 14th day after stroke or death in Group 1 included the neurological state on the 1st day following stroke. CONCLUSIONS: Anemia appeared in approximately 1/3 patients suffering a stroke. Slight or moderate anemia in the acute period of stroke did not significantly influence the neurological or functional status in the acute phase of stroke. The neurological state on the first day is an independent factor of a poor prognosis in patients with anemia in short-term follow-up.
PL
WSTĘP: Anemia jest czynnikiem ryzyka chorób sercowo-naczyniowych. Celem badania była ocena potencjalnego wpływu niedokrwistości na stan neurologiczny pacjentów w pierwszej dobie oraz funkcjonalny w 14 dobie od wystąpienia niedokrwiennego udaru mózgu. MATERIAŁ I METODY: Do prospektywnego badania włączono 109 pacjentów (w tym 53 kobiety) w wieku 72,8 ± 11,12 w pierwszej dobie pierwszego w życiu udaru mózgu. Porównano częstość wybranych chorób i parametrów biochemicznych, stan neurologiczny (wg NIHSS) w pierwszej oraz stan funkcjonowania (wg mRankin) w 14 dobie od wystąpienia udaru mózgu u pacjentów z anemią oraz prawidłowym stężeniem hemoglobiny. WYNIKI: Anemię stwierdzono u 34 pacjentów (15 kobiet oraz 19 mężczyzn) oraz 8 pacjentów w wieku ≤ 65 r.ż. Częstość lekkiego i umiarkowanego/ciężkiego deficytu neurologicznego w pierwszej dobie nie różniła się znamiennie między pacjentami z anemią i bez anemii. Częstość stanu funkcjonalnego na poziomie 3–5 Rankin w 14 dobie oraz zgonu (do 14 dni od zachorowania) nie różniła się znamiennie między tymi pacjentami. Stan neurologiczny pacjentów z anemią w pierwszej dobie udaru mózgu okazał się niezależnym czynnikiem gorszego rokowania odnośnie do stanu funkcjonalnego w 14 dobie udaru mózgu oraz zgonu do 14 doby od zachorowania. WNIOSKI: Niedokrwistość występuje u ok. 1/3 pacjentów z ostrym niedokrwiennym udarem mózgu. Lekka oraz umiarkowana niedokrwistość nie wykazuje istotnego negatywnego wpływu na stan neurologiczny oraz funkcjonalny pacjentów w ostrym okresie udaru. Stan neurologiczny w pierwszej dobie udaru niedokrwiennego jest niezależnym czynnikiem złego rokowania w obserwacji krótkoterminowej u pacjentów z anemią.
Keywords
EN
Year
Volume
70
Pages
281–285
Physical description
References
  • 1. Saxena K., Ranalli M., Khan N., Blanchong C., Kahwash S.B. Fatal stro-ke in a child with severe iron deficiency anemia and multiple hereditary risk factors for thrombosis. Clin. Pediatr. 2005; 44: 175–180.
  • 2. Roger V.L., Go A.S., Lloyd-Jones D.M., Benjamin E.J., Berry J.D., Bor-den W.B., Bravata D.M., Dai S., Ford E.S., Fox C.S., Fullerton H.J., Gillespie C., Hailpern S.M., Heit J.A., Howard V.J., Kissela B.M., Kittner S.J., Lack-land D.T., Lichtman J.H., Lisabeth L.D., Makuc D.M., Marcus G.M., Marelli A., Matchar D.B., Moy C.S., Mozaffarian D., Mussolino M.E., Nichol G., Paynter N.P., Soliman E.Z., Sorlie P.D., Sotoodehnia N., Turan T.N., Virani S.S., Wong N.D., Woo D., Turner M.B. Heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation 2012; 125: e2–e220.
  • 3. Maguire J.L., deVeber G., Parkin P.C. Association between iron-deficiency anemia and stroke in young children. Pediatrics 2007; 120: 1053–1057.
  • 4. Azab S.F., Abdelsalam S.M., Saleh S.H., Elbehedy R.M., Lotfy S.M., Esh A.M., Srea M.A., Aziz K.A. Iron deficiency anemia as a risk factor for cerebrovascular events in early childhood: a case-control study. Ann Hematol. 2014; 93: 571–576.
  • 5. Tegos T.J., Kalodiki E., Daskalopoulou S.S., Nicolaides A.N. Stroke: epidemiology, clinical picture, and risk factors – Part I of III. Angiology. 2000; 51: 793–808.
  • 6. Driscoll M.C., Hurlet A., Styles L., McKie V., Files B., Olivieri N., Pe-gelow C., Berman B., Drachtman R., Patel K., Brambilla D. Stroke risk in siblings with sickle cell anemia. Blood. 2003; 101: 2401–2404.
  • 7. Huang W.Y., Chen I.C., Meng L., Weng W.C., Peng T.I. The influence of anemia on clinical presentation and outcome of patients with first-ever atherosclerosis-related ischemic stroke. J. Clin. Neurosci. 2009; 16: 645–649.
  • 8. Nybo M., Kristensen S.R., Mickley H., Jensen J.K. The influence of anaemia on stroke prognosis and its relation to N-terminal pro-brain natriuretic peptide. Eur. J. Neurol. 2007; 14: 477–482.
  • 9. Tanne D., Molshatzki N., Merzeliak O., Tsabari R., Toashi M., Schwam-menthal Y. Anemia status, hemoglobin concentration and outcome after acute stroke: a cohort study. BMC Neurol. 2010; 10: 22.
  • 10. The World Bank. World Development Report 1993. Investing in health. Oxford University Press, Oxford 1993.
  • 11. Jauch E.C., Saver J.L., Adams H.P. Jr, Bruno A., Connors J.J., De-maerschalk B.M., Khatri P., McMullan P.W. Jr, Qureshi A.I., Rosenfield K., Scott P.A., Summers D.R., Wang D.Z., Wintermark M., Yonas H. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013; 44: 870–947.
  • 12. Beutler E., Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood 2006; 107: 1747–1750.
  • 13. Young F.B., Weir C.J., Lees K.R. GAIN International Trial Steering Committee and Investigators. Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials. Stroke 2005; 36: 2187–2192.
  • 14. Weisscher N., Vermeulen M., Roos Y.B., de Haan R.J. What should be defined as good outcome in stroke trials; a modified Rankin score of 0–1 or 0–2? J. Neurol. 2008; 255: 867–874.
  • 15. Sabatine M.S., Morrow D.A., Giugliano R.P., Burton P.B., Murphy S.A., McCabe C.H., Gibson C.M., Braunwald E. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation 2005; 111: 2042–2049.
  • 16. Lawler P.R., Filion K.B., Dourian T., Atallah R., Garfinkle M., Eisenberg M.J. Anemia and mortality in acute coronary syndromes: a systematic review and meta-analysis. Am. Heart J. 2013; 165: 143–153.
  • 17. Bowling C.B., Muntner P., Bradbury B.D., Kilpatrick R.D., Isitt J.J., Warriner A.H., Curtis J.R., Judd S., Brown C.J., Allman R.M., Warnock D.G., McClellan W. Low hemoglobin levels and recurrent falls in U.S. men and women: prospective findings from the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. Am. J. Med. Sci. 2013; 345: 446–454.
  • 18. Penninx B.W., Pahor M., Woodman R.C., Guralnik J.M. Anemia in old age is associated with increased mortality and hospitalization. J. Gerontol. A. Biol. Sci. Med. Sci. 2006; 61: 474–479.
  • 19. Penninx B.W., Pluijm S.M., Lips P., Woodman R., Miedema K., Guralnik J.M., Deeg D.J. Late-life anemia is associated with increased risk of recurrent falls. J. Am. Geriatr. Soc. 2005; 53: 2106–2111.
  • 20. Shah R.C., Wilson R.S., Tang Y., Dong X., Murray A., Bennett D.A. Relation of hemoglobin to level of cognitive function in older persons. Neuroepidemiology 2009; 32: 40–46.
  • 21. Dong X., Mendes de Leon C., Artz A., Tang Y., Shah R., Evans D.A. population-based study of hemoglobin, race, and mortality in elderly persons. J. Gerontol. A. Biol. Sci. Med. Sci. 2008; 63: 873–878.
  • 22. Culleton B.F., Manns B.J., Zhang J., Tonelli M., Klarenbach S., Hemmelgarn B.R. Impact of anemia on hospitalization and mortality in older adults. Blood 2006; 107: 3841–3846.
  • 23. Diedler J., Sykora M., Hahn P., Heerlein K., Schölzke M.N., Kellert L., Bösel J., Poli S., Steiner T. Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage. Crit. Care. 2010; 14: R63.
  • 24. Hemphill J.C., Bonovich D.C., Besmertis L., Manley G.T., Johnston S.C. The ICH score: a simple, reliable grading scale for intracerebral he-morrhage. Stroke 2001; 32: 891–897.
  • 25. Kumar M.A., Rost N.S., Snider R.W., Manley G.T., Johnston S.C. Anemia and hematoma volume in acute intracerebral hemorrhage. Crit. Care. Med. 2009; 37: 1442–1447.
  • 26. Dubyk M.D., Card R.T., Whiting S.J., Boyle C.A., Zlotkin S.H., Paterson P.G. Iron deficiency anemia prevalence at first stroke or transient ischemic attack. Can. J. Neurol. Sci. 2012; 39(2): 189–195.
  • 27. Koennecke H.C., Belz W., Berfelde D., Endres M., Fitzek S., Hamilton F., Kreitsch P., Mackert B.M., Nabavi D.G., Nolte C.H., Pöhls W., Schmehl I., Schmitz B., von Brevern M., Walter G., Heuschmann P.U. Factors in-fluencing in-hospital mortality and morbidity in patients treated on a stroke unit. Neurology 2011; 77: 965–972.
  • 28. Kim J.S., Kang S.Y., Grines C.L., Cox D.A., Garcia E., Mehran R., Tcheng J.E., Griffin J.J., Guagliumi G., Stuckey T., Turco M., Cohen D.A., Negoita M., Lansky A.J., Stone G.W. Bleeding and subsequent anemia: a precipitant for cerebral infarction. Eur. Neurol. 2000; 43: 201–208.
  • 29. Nikolsky E., Aymong E.D., Halkin A. Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: analysis from the Controlled Abciximab and Device Inve-stigation to Lower Late Angioplasty Complications (CADILLAC) Trial. J. Am. Coll. Cardiol. 2004; 44: 547–553.
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article
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YADDA identifier
bwmeta1.element.psjd-e7e9be3e-4dc7-439a-ac3f-4d12da77784e
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