PL EN


Preferences help
enabled [disable] Abstract
Number of results
2012 | 17 | 79 - 86
Article title

INVESTIGATION OF FENOFIBRATE SOLUBILITY IN THE PRESENCE OF CHITOSAN

Content
Title variants
Languages of publication
EN
Abstracts
EN
Fenofibrate is an active substance which is well absorbed from the gastrointestinal tract, but it is characterized by limited solubility. Due to a wide spectrum of its pharmacological activity, it would be beneficial to improve its solubility, and thus increase the drug absorption capability. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions at the drug to polymer ratio of 3:7,5:5,7:3. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 33 to 50 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
Keywords
Publisher

Year
Volume
17
Pages
79 - 86
Physical description
Contributors
author
  • Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw
References
  • Woskowicz M; (2008) Biofarmaceutyczny system klasyfikacji (BCS) jako nowoczesna metoda oceny właściwości fizykochemicznych i farmakokinetycznych środków leczniczych. Farmacja Polska 64, pp. 191-195.
  • Amidon GL, Lennernäs H, Shah VP, Crison JR; (1995) A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability; Pharm. Res. 12 (3), pp. 413-420.
  • Petkow-Dimitrow P; (2007) Plejotropowe działanie fenofibratu. Czynniki Ryzyka 1, pp. 57-63.
  • Vasconcelos Sarmento B, Costa P; (2007) Solid dispersions as a strategy to improve oral bioavailability of poor water soluble drugs. Drug Discovery Today 12, pp. 1068-1075.
  • Dhirendra K, Lewis S, Udupa N, Atin K; (2009) Solid dispersions: a review; Pak. J. Pharm. Sci,. 22 (2), 234-246.
  • Patel T, Patel LD, Makwana S; (2010) Enhancement of dissolution of fenofibrate by solid dispersion technique. Int. J. Res. Pharm. Sci., 1,(2),pp. 127-132.
  • Farmakopea Polska VII; (2007) Uwalnianie substancji ze stałych postaci leku;suplement,pp. 1417- 1425.
  • Yasir M, Asif M, Kumar A, Aggarval A; (2010) Biopharmaceutical Classification System: An Account; Int. J. of Pharm. Tech. Res., 2,(3), 1681-1690.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-e6dada6e-f668-419f-8d2b-478799c94ade
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.