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2019 | 118 | 100-114
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Synthesis, characterization and docking studies of some novel xanthene derivatives

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The synthesis of a novel xanthene derivatives bearing dimedone as an excellent precursor has been achieved by applying one pot three component Hantzsch type condensation. The newly synthesized compounds were characterized by spectral and elemental analyses. All synthesized compounds undergo docking studies and biological screening for antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungal species. Among all the tested compounds, it was found that compound 3c, 3d, 3g and 3h revealed better activities against the Gram-positive rather than the Gram-negative bacteria whereas results of docking studies revealed that compounds 3b, 3g and 3i showed best binding affinity towards ATP binding pocket of Human PIM1 kinase receptor through steric favorable and H-bond interactions.
Physical description
  • Department of Chemistry, Kamani Science & Prataprai Arts College, Amreli, Gujarat, India
  • Department of Chemistry, Kamani Science & Prataprai Arts College, Amreli, Gujarat, India
  • Department of Life Sciences, Gujarat University, Ahmedabad, Gujarat, India
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